Evidence map›Paper›PMID 32303914›Full record

ArticleNeuroscience bulletin2020

EPAC Negatively Regulates Myelination via Controlling Proliferation of Oligodendrocyte Precursor Cells.

Zhen-Zhen Gao, Ying-Cong Li, Chong-Yu Shao, Jian Xiao, Ying Shen, Liang Zhou

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Role of EPAC1 in chronic pain.Biochemistry and biophysics reports · 2024
    Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Zhen-Zhen GaoMolecular Pharmacology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Ying-Cong LiDepartment of Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Chong-Yu ShaoDepartment of Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Jian XiaoMolecular Pharmacology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Ying ShenDepartment of Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China. yshen@zju.edu.cn.ORCID http://orcid.org/0000-0001-7034-5328
Liang ZhouDepartment of Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310058, China. zllzlj@zju.edu.cn.
Zhejiang University · CNWenzhou Medical University · CNZunyi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence suggests that a cyclic adenosine monophosphate (cAMP)-dependent intracellular signal drives the process of myelination. Yet, the signal transduction underlying the action of cAMP on central nervous system myelination remains undefined. In the present work, we sought to determine the role of EPAC (exchange protein activated by cAMP), a downstream effector of cAMP, in the development of the myelin sheath using EPAC1 and EPAC2 double-knockout (EPAC

Indexed as

Cell ProliferationGuanine Nucleotide Exchange FactorsOligodendrocyte Precursor CellsAnimalsCyclic AMPMiceMice, KnockoutMyelin SheathCyclic AMPEpac protein, mouseGuanine Nucleotide Exchange FactorsEPACMyelinationOligodendrocyteProliferationTranscription factor

Identifiers

PMID32303914
PMCPMC7270323
OpenAlexW3017101144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.