Evidence map›Paper›PMID 32303904›Full record

SynthesisEndocrine2020

Rs9939609 polymorphism of the fat mass and obesity-associated (FTO) gene and metabolic syndrome susceptibility in the Chinese population: a meta-analysis.

Dong Wang, Zhihong Wu, Jun Zhou, Xiaotian Zhang

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Endocrine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Association of fat mass and obesity-associated (Journal of diabetes and metabolic disorders · 2022
    Review
  8. Review
  9. Association between theNutrients · 2021
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Dong Wang *Department of Cardiology, Wuhan No.1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhihong Wu *Department of Rheumatology, Wuhan No.1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jun ZhouDepartment of Cardiology, Wuhan No.1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. dr_zhoujun6188@163.com.
Xiaotian ZhangHubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan, China. xtzhang@mail.bnu.edu.cn.
Huazhong University of Science and Technology · CNHubei Provincial Center for Disease Control and Prevention · CN

Funding

Hubei Provincial Population and Family Planning Commission WJ2019Q054Natural Science Foundation of Hubei Province 2019CFB405
6 · The paper itself

Abstract

purposeThe relationship between the rs9939609 allele of fat mass and obesity-associated (FTO) gene and metabolic syndrome (MS) susceptibility has been evaluated by many studies, however, the results still remained controversial in the Chinese population. In order to provide more accurate results, we performed this meta-analysis.

methodsWe searched PubMed, and Wanfang Med Online in both English and Chinese, and eight eligible studies comprising of 5345 cases and 9523 controls were eventually selected into our meta-analysis. The meta-analysis was performed using the STATA 12.0 software.

resultsIn pooled analysis, the FTO gene rs9939609 polymorphism significantly increased MS susceptibility under per-allele comparisons (A vs. T) (OR 1.21, 95% CI 1.10-1.35, P < 0.001) and in dominant model (OR 1.35, 95% CI 1.13-1.62, P < 0.001). Subgroup analyses under per-allele comparisons (A vs. T) indicated that the elevated risk was observed in adults (OR 1.26, 95% CI 1.08-1.47, P = 0.003) but not in children and adolescents (OR 1.14, 95% CI 0.95-1.36, P = 0.17), and that the risk for increasing MS was only identified in IDF groups (OR 1.22, 95% CI 1.03-1.43, P = 0.018) but not in NCEP ATP III groups (OR 1.14, 95% CI 0.95-1.36, P = 0.17); in both population-based (PB) and hospital-based (HB) groups, A alleles of rs9939609 appeared to be linked to increased MS susceptibilities (HB group: OR 1.51, 95% CI 1.10-2.08, P = 0.01; PB group: OR 1.19, 95% CI 1.09-1.30, P < 0.001). No significant association was established in dominant model subgroup analyses except PB group (OR 1.29, 95% CI 1.05-1.53, P < 0.001).

conclusionOur results suggested that the FTO gene rs9939609 polymorphism significantly increased MS susceptibility in Chinese. Our results should be verified by well-designed studies with larger sample size.

Indexed as

Metabolic SyndromeAdolescentAdultAlpha-Ketoglutarate-Dependent Dioxygenase FTOBody Mass IndexChildChinaGenetic Predisposition to DiseaseGenotypeHumansObesityPolymorphism, Single NucleotideAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanFTO geneMeta-analysisMetabolic syndromePolymorphismrs9939609

Identifiers

PMID32303904
OpenAlexW3017304829

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.