Observational studyJournal of anesthesia2020
Effect of scheduled intravenous acetaminophen on postoperative nausea and vomiting in patients undergoing laparoscopic gynecologic surgery.
Observational study in Journal of anesthesia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Efficacy of intravenous acetaminophen on postoperative shivering: A meta-analysis of randomized controlled trials.Medicine · 2024Pooled it
- Effect of the intravenous acetaminophen clinical pathway on postoperative analgesia in spinal fusion surgery.Scientific reports · 2025Observational
- Routine use of intravenous acetaminophen safely enhances pain control after minimally invasive hepatectomies: a retrospective cohort study.BMC surgery · 2025Article
- Enhanced recovery after surgery, current, and future considerations in head and neck cancer.Laryngoscope investigative otolaryngology · 2023Review
- Historical Changes in Anesthesia Practice for Laparoscopic Gynecological Surgery at Juntendo University Hospital - A Retrospective Observational Study Focusing on Factors Affecting the Incidence of Postoperative Nausea and Vomiting.Juntendo Iji zasshi = Juntendo medical journal · 2022Article
- Assessment of pain and postoperative nausea and vomiting and their association in the early postoperative period: an observational study from Palestine.BMC surgery · 2021Observational
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to assess the effect of scheduled intravenous acetaminophen (SIVA) on the incidence of postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic gynecologic surgery (LGS).
methodsThis retrospective observational study identified consecutive patients who underwent LGS at our institution from January to November of 2017 and were managed with either our hospital's old protocol (Group H) or a new protocol using SIVA (Group S). Primary outcomes included the incidences of PONV and the amount of additional antiemetic required in the postoperative period. The secondary outcomes included the pain score on postoperative day 1, the requirement for additional analgesic medications, and the length of hospitalization (LOH).
resultsPatients in Group S had significantly lower incidences of PONV from postoperative days 0 to 1 and required significantly less antiemetics or tramadol than those in Group H (P = 0.0085). Patients at a low risk for PONV in Group S had significantly lower incidences of PONV than those in Group H (P = 0.0129). Further, the amount of additional tramadol required was lower in Group S than in Group H (P = 0.0021).
conclusionIntroduction of SIVA into the postoperative pain management protocol of LGS may reduce the incidence of PONV and the amount of adjunctive antiemetic medication required from postoperative days 0 to 1. In patients undergoing LGS, PONV prophylaxis using antiemetics should be prescribed depending on PONV risk profile; however, SIVA prophylaxis can be used in all patients regardless of PONV risk profile.
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