ArticleInflammation2020
A Follicle-Stimulating Hormone Exacerbates the Progression of Periapical Inflammation Through Modulating the Cytokine Release in Periodontal Tissue.
Article in Inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Menopause and vascular endothelial health: Is it all about the oestrogen?Experimental physiology · 2026Review
- The Hypothalamic-Pituitary-Ovarian Axis, Ovarian Disorders, and Brain Aging.Endocrinology · 2025Review
- Effects of ovariectomy-induced osteoporosis and two photobiomodulation protocols on the repair of apical periodontitis in Wistar rats: A microCT study.International endodontic journal · 2025Article
- Helper T cells: A potential target for sex hormones to ameliorate rheumatoid arthritis? (Review).Molecular medicine reports · 2024Review
- Bivariate genome-wide association study of circulating fibrinogen and C-reactive protein levels.Journal of thrombosis and haemostasis : JTH · 2024Article
- Influence of Osteoporosis on the Course of Apical Periodontitis.European journal of dentistry · 2024Article
- The Molecular Comorbidity Network of Periodontal Disease.International journal of molecular sciences · 2024Article
- Linking alterations in estrogen receptor expression to memory deficits and depressive behavior in an ovariectomy mouse model.Scientific reports · 2024Article
- An Array SPRi Biosensor for the Determination of Follicle-Stimulating Hormone in Blood Plasma.Sensors (Basel, Switzerland) · 2023Article
- Review of mendelian randomization studies on age at natural menopause.Frontiers in endocrinology · 2023Review
- Osteoporosis and Alveolar Bone Health in Periodontitis Niche: A Predisposing Factors-Centered Review.Cells · 2022Review
- High Follicle-Stimulating Hormone Level Associated With Risk of Rheumatoid Arthritis and Disease Activity.Frontiers in endocrinology · 2022Article
- Age, Sex, and Depot-Specific Differences in Adipose-Tissue Estrogen Receptors in Individuals with Obesity.Obesity (Silver Spring, Md.) · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Menopause is directly related to a systemically low grade of inflammation, indicating that postmenopausal women might be more prone to the development of inflammation. The high levels of circulating follicle-stimulating hormone (FSH) may cause hypogonadal bone loss during postmenopausal osteoporosis independent of estrogen. Previous research revealed that FSH could aggravate alveolar bone loss during experimental periapical lesions in ovariectomized rats; however, the mechanisms for these effects remain unclear. In this study, we showed that FSH enhanced the expression and secretion of the proinflammatory cytokines interleukin (IL)-1β, IL-6, and tumor necrosis factor alpha to a significant degree in human periodontal ligament (hPDL) cells. Furthermore, FSH upregulated Porphyromonas gingivalis lipopolysaccharide (pg LPS)-induced proinflammatory cytokine production. Furthermore, in vivo studies demonstrated that FSH increased the levels of the aforementioned cytokines in the serum and enhanced the expression of Toll-like receptor 4 at both the messenger RNA and protein levels in hPDL cells and periodontal tissues. Our research suggests that high FSH levels may regulate the immune status of periodontal tissues during the postmenopausal period and, to a certain extent, suggested that postmenopausal women might be more prone to the development of inflammation of the periapical periodontitis and more obvious bone loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.