Evidence map›Paper›PMID 32303761›Full record

ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2020

Pregnant Smokers Receiving Opioid Agonist Therapy Have an Elevated Nicotine Metabolite Ratio: A Replication Study.

Henry R Kranzler, Yukiko Washio, Leah R Zindel, Kevin G Lynch, Dennis Hand, Rachel F Tyndale, Cheryl Oncken, Robert Schnoll

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06576323 (An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS Care), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06576323 narecruitingnot on this mapstarted 2024, after this paper: background citation

An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS Care

TypeinterventionalSponsorUniversity of PennsylvaniaRan2024 to 2027Enrolled50ConditionsOpioid Use Disorder, Neonatal Abstinence SyndromeArmsAn implementation model for co-located Medications for Opioid Use Disorder (MOUD) prescription in the NICU
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Neonatal Outcomes after Combined Opioid and Nicotine Exposure in Utero: A Scoping Review.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Henry R KranzlerCenter for Studies of Addiction, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Yukiko WashioSubstance Use, Gender and Applied Research, RTI International, Research Triangle Park, NC.
Leah R ZindelCenter for Studies of Addiction, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Kevin G LynchCenter for Studies of Addiction, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Dennis HandDepartments of Obstetrics & Gynecology and Psychiatry & Human Behavior, Thomas Jefferson University, Philadelphia, PA.
Rachel F TyndaleCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.
Cheryl OnckenDepartments of Medicine and Obstetrics and Gynecology, University of Connecticut School of Medicine, Farmington, CT.
Robert SchnollCenter for Interdisciplinary Research on Nicotine Addiction, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
University of Pennsylvania · USCentre for Addiction and Mental Health · CARTI International · USThomas Jefferson University · USUniversity of Connecticut · US

Funding

Placebo-controlled trial of bupropion for smoking cessation in pregnant womenR01CA184315 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KRANZLER, HENRY RICHARD · 2014 to 2018
$3.2M
CIHR FDN-154294NCI NIH HHS R01 CA184315
6 · The paper itself

Abstract

introductionPregnant women exposed chronically to opioids smoked more cigarettes per day (CPD) and had a higher nicotine metabolite ratio (NMR), 3-hydroxycotinine/cotinine, a biomarker of nicotine metabolism and clearance, than those not receiving opioids. We examined CPD and NMR in a group of pregnant smokers, a quarter of whom were receiving opioid agonist therapy (OAT). AIMS AND

methodsPregnant smokers recruited to participate in a placebo-controlled trial of bupropion for smoking cessation provided a blood sample for measurement of NMR.

resultsHalf (52.4%) of the 124 women with NMR data were African American. OAT-treated women (n = 34, 27.4%; 27 receiving methadone and 7 buprenorphine) were more likely to be white (79% vs. 30%, p < .001) and to have a lower mean PHQ-9 total score (2.91 [SD = 2.83] vs. 4.83 [SD = 3.82], p = .007). OAT-treated women reported smoking more CPD (9.50 [SD = 5.26] vs. 7.20 [SD = 3.65], p = .005) and had higher NMR (0.78 [SD = 0.36] vs. 0.56 [SD = 0.25], p = .001) than the non-OAT-treated group. In a linear regression analysis adjusting for race, depression severity, and CPD, NMR was greater in the OAT group (p = .025), among whom the daily methadone-equivalent dosage correlated with NMR (Spearman's ρ = 0.49, p = .003).

conclusionsConsistent with the findings of Oncken et al. (2019), we found that OAT smokers smoked more and had higher NMR than non-OAT smokers. As higher NMR is associated with a reduced likelihood of smoking cessation, the effects on NMR of both pregnancy and OAT could contribute to a lower smoking cessation rate in pregnant smokers receiving chronic opioid therapy. IMPLICATIONS: We replicated the finding that the NMR is significantly greater among pregnant smokers receiving OAT than those not receiving this treatment for opioid use disorder. Furthermore, we found that the dosage of the OAT was significantly associated with the NMR level. These findings may contribute to a poorer response to smoking cessation treatment in pregnant women treated with OAT, particularly those receiving high-dose therapy, and raise the question of whether novel approaches are needed to treat smoking in this subgroup of pregnant smokers.

Indexed as

CotinineOpiate Substitution TreatmentAnalgesics, OpioidBupropionFemaleHumansMethadoneNicotineOpioid-Related DisordersPregnancyPregnancy ComplicationsSmokingSmoking CessationAnalgesics, OpioidBupropionCotinineMethadoneNicotine

Identifiers

PMID32303761
PMCPMC7542647
OpenAlexW3016886601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.