ArticleProceedings of the National Academy of Sciences of the United States of America2020
Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54citing papers in PubMed
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Who cites it
54 citing papers in PubMed, 73 citations in OpenAlex.
- Mesenchymal stem cell-derived extracellular vesicle treatment of induced pluripotent stem cell-derived motor neurons with different amyotrophic lateral sclerosis genetic backgrounds.Neural regeneration research · 2026Article
- Lysosomal dysfunction in neurodegenerative disease.Nature reviews. Neurology · 2026Review
- The C9orf72/SMCR8 complex maintains microglial homeostasis via RAB8A-ESCRT-mediated lysosomal repair.The EMBO journal · 2026Article
- The Activation of ARF1 Is Dynamically Regulated by its Palmitoylation.Molecular & cellular proteomics : MCP · 2026Article
- C9orf72 in myeloid cells prevents an inflammatory response to microbial glycogen.Cell reports · 2026Article
- Inhibition of PolyGA Dipeptide Repeat Protein Aggregation by Nucleic Acid Aptamers in C9 Amyotrophic Lateral Sclerosis-Frontotemporal Dementia Models.Molecular neurobiology · 2025Article
- Cryo-EM structure of the human MON1A-CCZ1-RAB7A complex provides insights into nucleotide exchange mechanism.Life metabolism · 2025Article
- BiDAC-dependent degradation of plasma membrane proteins by the endolysosomal system.Nature communications · 2025Article
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- Myeloid and lymphoid expression ofScience translational medicine · 2024Article
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- Acetyl-L-carnitine and Amyotrophic Lateral Sclerosis: Current Evidence and Potential use.CNS & neurological disorders drug targets · 2024Review
- Role of C9orf72 hexanucleotide repeat expansions in ALS/FTD pathogenesis.Frontiers in molecular neuroscience · 2024Review
- ALS-linked C9orf72-SMCR8 complex is a negative regulator of primary ciliogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The endolysosomal pathway and ALS/FTD.Trends in neurosciences · 2023Review
- Pathological insights from amyotrophic lateral sclerosis animal models: comparisons, limitations, and challenges.Translational neurodegeneration · 2023Review
- Mitochondrial Dysfunction in Repeat Expansion Diseases.Antioxidants (Basel, Switzerland) · 2023Review
- Article
- Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives.Cells · 2023Review
- C9ORF72 suppresses JAK-STAT mediated inflammation.iScience · 2023Article
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Authors and funding
18 authors at 2 institutions in 1 country.
Dan TangDepartment of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, 610041 Chengdu, China.
Jingwen ShengDepartment of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, 610041 Chengdu, China.
Liangting XuDepartment of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, 610041 Chengdu, China.ORCID 0000-0002-9168-0931
Xiechao ZhanBeijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, 10084 Beijing, China.
Jiaming LiuDepartment of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, 610041 Chengdu, China.
Hui JiangDepartment of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, 610041 Chengdu, China.
Xiaoling ShuDepartment of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, 610041 Chengdu, China.
Xiaoyu LiuDepartment of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, 610041 Chengdu, China.
Tizhong ZhangDepartment of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, 610041 Chengdu, China.ORCID 0000-0001-8986-438X
Lan JiangDepartment of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, 610041 Chengdu, China.
Cuiyan ZhouBeijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, 10084 Beijing, China.
Wenqi LiBeijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, 10084 Beijing, China.
Wei ChengDepartment of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, 610041 Chengdu, China.
Zhonghan LiDepartment of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, 610041 Chengdu, China.
Kunjie WangDepartment of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, 610041 Chengdu, China.
Kefeng LuDepartment of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, 610041 Chengdu, China.
Chuangye YanBeijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, 10084 Beijing, China; yancy2019@mail.tsinghua.edu.cn qishiqian@scu.edu.cn.ORCID 0000-0001-9338-8048
Shiqian QiDepartment of Urology, State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, 610041 Chengdu, China; yancy2019@mail.tsinghua.edu.cn qishiqian@scu.edu.cn.ORCID 0000-0002-7589-8877
Sichuan University · CNCenter for Life Sciences · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
A massive intronic hexanucleotide repeat (GGGGCC) expansion in
Indexed as
Amino Acid SequenceAmyotrophic Lateral SclerosisArginineAutophagyAutophagy-Related ProteinsC9orf72 ProteinCarrier ProteinsCryoelectron MicroscopyFilaminsFrontotemporal DementiaGenetic Predisposition to DiseaseGTPase-Activating ProteinsHumansMultiprotein Complexesrab11 GTP-Binding Proteinsrab GTP-Binding ProteinsArginineAutophagy-Related ProteinsC9orf72 ProteinC9orf72 protein, humanCarrier ProteinsFilaminsFLNC protein, humanFNIP2 protein, humanGTPase-Activating ProteinsMultiprotein Complexesrab11 GTP-Binding ProteinsRAB8A protein, humanrab GTP-Binding ProteinsSMCR8 protein, humanWDR41 protein, humanC9ORF72cryo-EMGAP activitySMCR8WDR41
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.