ArticleApplied and environmental microbiology2020
Rapid Reconstitution of the Fecal Microbiome after Extended Diet-Induced Changes Indicates a Stable Gut Microbiome in Healthy Adult Dogs.
Article in Applied and environmental microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Using meta-analysis to understand the impacts of dietary protein and fat content on the composition of fecal microbiota of domestic dogs (Canis lupus familiaris): A pilot study.MicrobiologyOpen · 2024Pooled it
- Temporal variability is an inherent feature of the healthy canine microbiome assessed by full-length 16S rRNA gene sequencing.Animal microbiome · 2026Article
- Characterization of the inflammatory response of a canine intestinal epithelial cell line challenged with lipopolysaccharides and/or butyrate.Journal of animal science · 2026Article
- BiombalanceAntioxidants (Basel, Switzerland) · 2025Article
- Effects of cRG-I Prebiotic Treatment on Gut Microbiota Composition and Metabolic Activity in Dogs In Vitro.Microorganisms · 2025Article
- Article
- A bi-variate framework to model microbiome resilience in healthy dogs.Frontiers in veterinary science · 2025Article
- Evaluating metagenomic analyses for undercharacterized environments: what's needed to light up the microbial dark matter?bioRxiv : the preprint server for biology · 2024Article
- Purified fibers in chemically defined synthetic diets destabilize the gut microbiome of an omnivorous insect model.bioRxiv : the preprint server for biology · 2024Article
- Decoding the Gut Microbiome in Companion Animals: Impacts and Innovations.Microorganisms · 2024Review
- Decoding huge phage diversity: a taxonomic classification of Lak megaphages.The Journal of general virology · 2024Article
- Conserved signatures of the canine faecal microbiome are associated with metronidazole treatment and recovery.Scientific reports · 2024Article
- Comprehensive profile of the companion animal gut microbiome integrating reference-based and reference-free methods.The ISME journal · 2024Article
- The effects of torula yeast as a protein source on apparent total tract digestibility, inflammatory markers, and fecal microbiota dysbiosis index in Labrador Retrievers with chronically poor stool quality.Journal of animal science · 2024Article
- Purified fibers in chemically defined synthetic diets destabilize the gut microbiome of an omnivorous insect model.Frontiers in microbiomes · 2024Article
- Research Progress on the Correlation Between Hypertension and Gut Microbiota.Journal of multidisciplinary healthcare · 2024Review
- A Novel Prebiotic Fibre Blend Supports the Gastrointestinal Health of Senior Dogs.Animals : an open access journal from MDPI · 2023Article
- Analysis of Intestinal Microbiota and Metabolic Pathways before and after a 2-Month-Long Hydrolyzed Fish and Rice Starch Hypoallergenic Diet Trial in Pruritic Dogs.Veterinary sciences · 2023Article
- Clinical response in dogs with acute hemorrhagic diarrhea syndrome following randomized probiotic treatment or fecal microbiota transplant.Frontiers in veterinary science · 2023Article
- The faecal metabolome of black howler monkeys (Alouatta pigra) varies in response to seasonal dietary changes.Molecular ecology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiome has an important role in health, and diet represents a key lever for shaping the gut microbiome across all stages of life. Maternal milk consumption in neonates leads to long-term health effects, indicating that pliability in the infant gut microbiome in response to diet can drive enduring change. The ability of diet to drive lasting changes in the adult gut microbiome is less understood. We studied the effect of an extreme dietary shift on the fecal microbiome of 46 Labrador retriever dogs (mean age, 4.6 years) over 11 months. Dogs were fed a nutritionally complete, commercially available complex diet (CD) for a minimum of 5 weeks, followed by highly purified diets (PDs) for 36 weeks, and the initial CD for at least a further 4 weeks. Fecal samples were collected at regular intervals for DNA extraction. By analyzing 16S rRNA genes and the metagenomes, we observed minor effects on microbial diversity but significant changes in bacterial taxa and genetic potential when a PD was fed. Specifically, metagenomics identified an enrichment of quinone- and GABA-related pathways on PD, providing insights into dietary effects on cross-feeding strategies impacting community structure. When dogs returned to the CD, no significant differences were found with the initial time point. These findings are consistent with the gut microbiome being rapidly adaptable but capable of being reconstituted when provided with similar diets. These data highlight that long-term changes in the adult dog gut microbiome may only be achieved through long-term maintenance on a specified diet, rather than through feeding a transitionary diet.
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