Evidence map›Paper›PMID 32303532›Full record

Observational studyBMJ open diabetes research & care2020

Glycemic responses to strenuous training in male professional cyclists with type 1 diabetes: a prospective observational study.

Olivia McCarthy, Max L Eckstein, Sam N Scott, Federico Y Fontana, Mark P Christiansen, Christoph Stettler, Miles Fisher, Bruce Bode, Michael C Riddell, Charlotte Hayes and 4 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in BMJ open diabetes research & care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Association of HbA1c with VOMetabolites · 2022
    Review
  4. Article
  5. Review
  6. Observational
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 6 countries.

Olivia McCarthyApplied Sports, Technology, Exercise and Medicine, Swansea University, Swansea, West Glamorgan, UK olivia.mccarthy@swansea.ac.uk.ORCID 0000-0001-6971-611X
Max L EcksteinCardiovascular Diabetology Research Group, Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Steiermark, Austria.
Sam N ScottResearch Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, UK.ORCID 0000-0003-2342-9865
Federico Y FontanaDepartment of Neurological and Movement Sciences, University of Verona, Verona, Veneto, Italy.
Mark P ChristiansenDiablo Clinical Research Center, Concord, California, USA.
Christoph StettlerDiabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0003-1691-6059
Miles FisherUniversity of Glasgow, Glasgow, Glasgow, UK.
Bruce BodeDepartment of Medicine, Emory University, Atlanta, Georgia, USA.
Michael C RiddellKinesiology and Health Science, York University, Toronto, Ontario, Canada.
Charlotte HayesTeam Novo Nordisk Professional Cycling Team, Atlanta, Georgia, USA.
Peter L LagrouTeam Novo Nordisk Academic and Clinical Advisors, Team Novo Nordisk Professional Cycling Team, Atlanta, Georgia, USA.
Phil SoutherlandTeam Novo Nordisk Professional Cycling Team, Atlanta, Georgia, USA.
Othmar MoserCardiovascular Diabetology Research Group, Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Steiermark, Austria.ORCID 0000-0002-1661-0685
Richard M BrackenApplied Sports, Technology, Exercise and Medicine, Swansea University, Swansea, West Glamorgan, UK.
Novo Nordisk (United States) · USMedical University of Graz · ATSwansea University · GBDiablo Clinical Research · USEmory University · USLiverpool John Moores University · GBUniversity of Bern · CHUniversity of Glasgow · GBUniversity of Verona · ITYork University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis prospective observational study sought to establish the glycemic, physiological and dietary demands of strenuous exercise training as part of a 9-day performance camp in a professional cycling team with type 1 diabetes (T1D). RESEARCH DESIGN AND

methodsSixteen male professional cyclists with T1D on multiple daily injections (age: 27±4 years; duration of T1D: 11±5 years; body mass index: 22±2 kg/m

resultsHigher levels of antecedent hypoglycemia in the nocturnal hours were associated with greater time spent in next-day hypoglycemia overall (p=0.003) and during exercise (p=0.019). Occurrence of nocturnal hypoglycemia was associated with over three times the risk of next-day hypoglycemia (p<0.001) and a twofold risk of low glucose during cycling (p<0.001). Moreover, there was trend for a greater amount of time spent in mild hypoglycemia during the night compared with daytime hours (p=0.080).

conclusionThe higher prevalence of nocturnal hypoglycemia was associated with an increased risk of next-day hypoglycemia, which extended to cycle training sessions. These data highlight the potential need for additional prebed carbohydrates and/or insulin dose reduction strategies around exercise training in professional cyclists with T1D. TRIAL REGISTRATION NUMBER: DRKS00019923.

Indexed as

Diabetes Mellitus, Type 1HypoglycemiaAdultBlood GlucoseGlycated HemoglobinHumansHypoglycemic AgentsMaleYoung AdultBlood GlucoseGlycated HemoglobinHypoglycemic AgentsCGMexerciseexercise traininghypoglycemia

Identifiers

PMID32303532
PMCPMC7199179
OpenAlexW3017339824

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.