Evidence map›Paper›PMID 32303281›Full record

ReviewSeminars in nephrology2020

The Utility of Human Kidney Organoids in Modeling Kidney Disease.

Aneta Przepiorski, Amanda E Crunk, Eugenel B Espiritu, Neil A Hukriede, Alan J Davidson

Abstract readReview
In one paragraph

Review in Seminars in nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Progress and breakthroughs in human kidney organoid research.Biochemistry and biophysics reports · 2024
    Review
  5. Stem cells for organoids.Smart medicine · 2022
    Review
  6. Review
  7. Article
  8. Bioprinting better kidney organoids.Nature materials · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aneta PrzepiorskiDepartment of Developmental Biology, University of Pittsburgh, School of Medicine, Pittsburgh, PA. Electronic address: ANETA@pitt.edu.
Amanda E CrunkDepartment of Developmental Biology, University of Pittsburgh, School of Medicine, Pittsburgh, PA.
Eugenel B EspirituDepartment of Developmental Biology, University of Pittsburgh, School of Medicine, Pittsburgh, PA.
Neil A HukriedeDepartment of Developmental Biology, University of Pittsburgh, School of Medicine, Pittsburgh, PA; Center for Critical Care Nephrology, University of Pittsburgh, School of Medicine, Pittsburgh, PA.
Alan J DavidsonDepartment of Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland, Auckland, New Zealand.

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Regulation of Renal Progenitor Cells in Regenerating KidneysR01DK069403 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HUKRIEDE, NEIL A · 2006 to 2020
$4.8M
Therapeutic Optimization of Productive Repair After Acute Kidney InjuryUC2DK126122 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAVIDSON, ALAN, DE CAESTECKER, MARK P. · 2020 to 2024
$3.2M
Renal and Epithelial Biology Training ProgramT32DK061296 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2002 to 2022
$3.1M
Utilizing Small Molecule Screens to Delineate Embryonic Signaling MechanismsR01HD053287 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HUKRIEDE, NEIL A, TSANG, MICHAEL WAIKOK · 2007 to 2016
$3.1M
High content in vivo screening for acute kidney injury ameliorating drugsR01DK112652 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HUKRIEDE, NEIL A, VOGT, ANDREAS · 2017 to 2019
$1.1M
NICHD NIH HHS R01 HD053287NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK069403NIDDK NIH HHS R01 DK112652NIDDK NIH HHS T32 DK061296NIDDK NIH HHS UC2 DK126122
6 · The paper itself

Abstract

The formation of three-dimensional kidney tissue (organoids) from human pluripotent stem cell lines provides a valuable tool to examine kidney function in an in vitro model and could be used for regenerative medicine approaches. Kidney organoids have the potential to model kidney diseases and congenital defects, be used for drug development, and to further our understanding of acute kidney injury, fibrosis, and chronic kidney disease. In this review, we examine the current stage of pluripotent stem cell-derived kidney organoid technology, challenges, shortcomings, and regenerative potential of kidney organoids in the future.

Indexed as

Induced Pluripotent Stem CellsKidneyOrganoidsRegenerationRenal Insufficiency, ChronicBiomedical ResearchCell DifferentiationCell LineCellular Reprogramming TechniquesDrug DevelopmentEmbryonic Stem CellsHumansIn Vitro TechniquesKidney DiseasesKidney Failure, ChronicPluripotent Stem Cellskidney diseaseKidney organoidspluripotent stem cells

Identifiers

PMID32303281
PMCPMC9003567

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.