SynthesisSubstance abuse treatment, prevention, and policy2020
The effects of opium on the cardiovascular system: a review of side effects, uses, and potential mechanisms.
Synthesis in Substance abuse treatment, prevention, and policy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Prevalence of opium use and use disorder in the Iranian population: A systematic review and meta-analysis.Addiction (Abingdon, England) · 2026Pooled it
- The effects of opium consumption on glycemic indices: a systematic review and meta-analysis of human and animal studies.BMC pharmacology & toxicology · 2025Pooled it
- Lipid profile dysregulation in opium users based on Fasa PERSIAN cohort study results.Scientific reports · 2021Trial
- Association Between Opium Consumption and Lipid Profile: A Systematic Review and Meta-Analysis of Observational Studies.Health science reports · 2026Article
- Potential Effects of Opium on Pro-inflammatory Cytokines in Coronary Artery Disease by Interfering with Anti-inflammatory Drugs.Current molecular medicine · 2026Article
- Effects of opium on cholesterol metabolism in rats fed normal and high-fat/high-cholesterol diet.Toxicology reports · 2025Article
- Persistent Opioid Use Following Major Orthopedic Surgery.Current pain and headache reports · 2025Review
- Opium Addiction and Coagulation Factors in ST-Segment Elevation Myocardial Infarction (STEMI) Patients: Implications for Thrombosis and Cardiovascular Outcomes.Iranian journal of public health · 2025Article
- Mechanistic Insights into the Anticancer Potential of Methoxyflavones Analogs: A Review.Molecules (Basel, Switzerland) · 2025Review
- Comparison of 10-year atherosclerotic cardiovascular disease (ASCVD) risk in metropolitan and rural areas of South of Iran.Scientific reports · 2025Article
- Sonographic features of internal carotid artery in patients with opioid use disorder: Is opium a new risk factor for atherosclerosis of internal carotid artery?Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Article
- Effective factors in nursing care for cardiovascular patients with opioid dependence disorder: A qualitative study.Journal of education and health promotion · 2025Article
- Evaluation of left ventricular systolic function in opium users by strain echocardiography.ESC heart failure · 2024Article
- Determination of Opium Alkaloid Content in Poppy Seeds Using Liquid Chromatography Coupled with a Mass Spectrometer with a Time-of-Flight Analyzer (UPLC-TOF-HRMS).Foods (Basel, Switzerland) · 2024Article
- Ceftriaxone and MC-100093 mitigate fentanyl-induced cardiac injury in mice: Preclinical investigation of its underlying molecular mechanisms.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Prevalence of major non-communicable diseases and their associated risk factors in Afghanistan: a systematic review and meta-analysis.Therapeutic advances in chronic disease · 2024Review
- Long-Term Effects of Opium Consumption Following Percutaneous Coronary Intervention: A 10-year Follow-Up Study.Global heart · 2024Article
- Opioid Use Disorder and intracerebral hemorrhage in Isfahan, Iran: a case-control study.Frontiers in neurology · 2024Article
- Prevalence and determinants of opioid use disorder among long-term opiate users in Golestan Cohort Study.BMC psychiatry · 2023Article
- Investigating the Relationship between Carotid Intima-Media Thickness (CIMT), Opium Addiction, and Components of the Metabolic Syndrome.Addiction & health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn Iran, as in many other Asian and Middle Eastern countries, some believe that opium has beneficial effects on cardiovascular system. Dependent patients suppose that opium has positive effects on cardiovascular function and can prevent or improve cardiovascular diseases; however, only few comprehensive studies evaluating such effects have been performed.
objectivesIn this study, we sought to clarify the effect of opium on cardiovascular problems by incorporating the previous findings and the current information on the issue and to explain the possible mechanisms of this effect.
methodsThe available human studies published up to October 30, 2019, were searched in different databases. Case-control, cohort, and cross-sectional studies were retrieved. Papers published in English or those with an English abstract were included. The risk of bias for each included study was assessed based on the Newcastle-Ottawa Scale (NOS). We then categorized the effects of opium on cardiovascular problems along with its probable underlying mechanisms of action.
resultsIn this study, most of the published articles suggested the adverse effects of opium on the cardiovascular system, including atherosclerosis, myocardial infarction, arrhythmia, low ejection fraction, and cardiovascular mortality; however, some articles reported the beneficial or impartial effects of opium on the cardiovascular system. In this article, we have categorized all the effects of opium on cardiovascular system; also, the proposed mechanisms of action of opium in each of the above-mentioned disorders are summarized.
conclusionAlthough the available evidences were incoherent, it was mostly suggested that opium use does not protect against or improve cardiovascular problems.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.