Evidence map›Paper›PMID 32303186›Full record

ArticleBMC medical genetics2020

Genetic factors in rotator cuff pathology: potential influence of col 5A1 polymorphism in outcomes of rotator cuff repair.

Stefano Petrillo, Umile Giuseppe Longo, Katia Margiotti, Vincenzo Candela, Caterina Fusilli, Giacomo Rizzello, Alessandro De Luca, Vincenzo Denaro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Stefano PetrilloProsthetic Surgery Centre, IRCCS Orthopedic Institute Galeazzi, via Riccardo Galeazzi 4, 20161, Milan, Italy.
Umile Giuseppe LongoDepartment of Orthopaedics and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy. g.longo@unicampus.it.
Katia MargiottiLaboratory of Molecular Medicine and Biotechnology, Campus-Bio Medico University of Rome, Rome, Italy.
Vincenzo CandelaDepartment of Orthopaedics and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy.
Caterina FusilliBioinformatics Unit, Casa Sollievo Della Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy.
Giacomo RizzelloDepartment of Orthopaedics and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy.
Alessandro De LucaUOS Diagnosi Genetica Molecolare Istituto CSS-Mendel, Viale Regina Margherita 261, 00198, Roma, Italy.
Vincenzo DenaroDepartment of Orthopaedics and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy.
Università Campus Bio-Medico · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITIstituto di Genetica Molecolare · ITIstituto Ortopedico Galeazzi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInvestigations in genetics have provided valuable information about the correlation between gene variants and tendinopathy. Single Nucleotide Polymorphisms of COL5A1 gene are reported to be involved in Achilles tendinopathy, chronic degenerative tendon changes at the elbow, and other tendinopathies. The influence of Single Nucleotide Polymorphisms of COL5A1 was previously analyzed in rotator cuff disease with confounding results. Moreover, the rs12722 polymorphism in COL5A1 gene has been implicated in the aetiology of musculoskeletal soft tissue injuries in several association studies. This study aims to analyse the possible influence of rs12722 polymorphism in COL5A1 in the outcomes of rotator cuff repair.

methodsSeventy-nine patients were included in the study. DNA was extracted from 1.2 ml of venous blood and genotyped for COL5A1 SNPs rs12722. Rotator cuff muscle strength and range of motion (ROM) in anterior elevation, external and internal rotation of the shoulder were evaluated.

resultsPatients presenting COL5A1 SNP rs12722 CC showed a ROM of passive external rotation statistically significantly higher compared to patients with CT genotype and TT genotype.

conclusionsCOL5A1 SNP rs12722 may influence the functional outcomes of RCRs, even though further studies are required to confirm these preliminary results.

Indexed as

Achilles TendonAdultAgedArthroscopyCollagen Type VFemaleGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideRotator CuffRotator Cuff InjuriesShoulderTendinopathyCOL5A1 protein, humanCollagen Type VArthroscopyCOL5A1 polymorphismOutcomesRotator cuff, geneticShoulder

Identifiers

PMID32303186
PMCPMC7165385
OpenAlexW3017331140

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.