ArticleBMC microbiology2020
Effects of resveratrol on cariogenic virulence properties of Streptococcus mutans.
Article in BMC microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Benefits and Implications of Resveratrol Supplementation on Microbiota Modulations: A Systematic Review of the Literature.International journal of molecular sciences · 2022Pooled it
- Resveratrol-loaded human dental pulp stem cell-derived exosomes enhance the efficacy of blue LED-mediated antimicrobial photodynamic therapy against mature cariogenic biofilms.Lasers in medical science · 2026Article
- α2-3-Sialylated Glycoproteins AttenuateInternational journal of molecular sciences · 2026Article
- Effectiveness of resveratrol as a root canal irrigation solution in inhibiting biofilm and bacterial metabolic activity of Enterococcus faecalis.Lasers in medical science · 2026Article
- Host-microbiome-immune disequilibrium in oral disease: mechanisms, dysbiosis, and precision therapeutics.Frontiers in immunology · 2026Review
- Application of Amino Acid-Based Carbon Dots for the Treatment of Oral Bacteria and Oral Cancer Cells In Vitro Using a Dental Light-Curing Unit via ROS-Mediated Therapy.Nanomaterials (Basel, Switzerland) · 2025Article
- Asiatic Acid Disrupts the Biofilm Virulence ofInternational journal of molecular sciences · 2025Article
- Inhibitory effects of berberine againstMicrobiology spectrum · 2025Article
- Evaluation of Physicochemical and Mechanical Properties of a Modified Adhesive System by Resveratrol Incorporation.Journal of functional biomaterials · 2025Article
- Promising potential effects of resveratrol on oral and dental health maintenance: a comprehensive review.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Cordycepin affects Streptococcus mutans biofilm and interferes with its metabolism.BMC oral health · 2025Article
- Natural compounds: new therapeutic approach for inhibition ofFrontiers in pharmacology · 2025Review
- Exploration of the primary antibiofilm substance and mechanism employed byFrontiers in cellular and infection microbiology · 2025Article
- [Research Progress on Drug Intervention to Inhibit Dental Plaque Biofilm Formation bySichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Review
- Antibacterial mechanism analysis of resveratrol against Salmonella typhimurium via metabolomics.Applied microbiology and biotechnology · 2024Article
- The effect of resveratrol application on the micro-shear bond strength of adhesive to bleached enamel.Scientific reports · 2024Article
- Antibacterial effect of resveratrol extract compared to chlorhexidine mouthwash against primary cariogenic pathogen, Streptococcus mutans.Journal of clinical and experimental dentistry · 2024Article
- Progress of Antimicrobial Mechanisms of Stilbenoids.Pharmaceutics · 2024Review
- Application of photosensitive dental materials as a novel antimicrobial option in dentistry: A literature review.Journal of dental sciences · 2024Review
- Anticariogenic activity of marine brown algaeFrontiers in cellular and infection microbiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundStreptococcus mutans is the principal etiological agent of human dental caries. The major virulence factors of S. mutans are acid production, acid tolerance, extracellular polysaccharide (EPS) synthesis and biofilm formation. The aim of this study is to evaluate the effect of resveratrol, a natural compound, on virulence properties of S. mutans.
resultsResveratrol at sub-MIC levels significantly decreased acid production and acid tolerance, inhibited synthesis of water-soluble polysaccharide and water-insoluble polysaccharide, compromised biofilm formation. Related virulence gene expression (ldh, relA, gtfC, comDE) was down-regulated with increasing concentrations of resveratrol.
conclusionsResveratrol has an inhibitory effect on S. mutans cariogenic virulence properties and it represents a promising anticariogenic agent.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.