Evidence map›Paper›PMID 32303182›Full record

Trial reportBMC anesthesiology2020

Effects of nitroglycerin versus labetalol on peripheral perfusion during deliberate hypotension for sinus endoscopic surgery: a randomized, controlled, double-blinded trial.

Marwa Zayed, Heba Nassar, Ahmed Hasanin, Amany H Saleh, Passaint Hassan, Dalia Saad, Sahar Mahmoud, Ghada Abo Bakr, Eman Fouad, Norhan Saleh and 2 more

Registry-linked trialOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03809065 (Effects of Nitroglycerin Versus Labetalol on Tissue Perfusion During Deliberate Hypotension for Sinus Endoscopic Surgery.), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03809065 phase4completednot on this map

Effects of Nitroglycerin Versus Labetalol on Tissue Perfusion During Deliberate Hypotension for Sinus Endoscopic Surgery.

TypeinterventionalSponsorCairo UniversityRan2019 to 2019Enrolled40ConditionsTissue Perfusion, Deliberate Hypotension, Sinus Endoscopic SurgeryArmsNitroglycerin, Labetalol
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Does preoperative administration of hypotensive agents affect the quality of the surgical field during endoscopic sinus surgery? A triple-blind randomized controlled trial.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Marwa ZayedDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt. marwa.zayed@kasralainy.edu.eg.
Heba NassarDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Ahmed HasaninDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Amany H SalehDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Passaint HassanDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Dalia SaadDepartment of Anesthesia and Critical Care Medicine, Faculty of Medicine, Cairo University, 01 elsarayah street, Elmanyal, Cairo, 11559, Egypt.
Sahar MahmoudDepartment of Anesthesia and Critical Care Medicine, Faculty of Medicine, Cairo University, 01 elsarayah street, Elmanyal, Cairo, 11559, Egypt.
Ghada Abo BakrDepartment of Anesthesia and Critical Care Medicine, Faculty of Medicine, Cairo University, 01 elsarayah street, Elmanyal, Cairo, 11559, Egypt.
Eman FouadDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Norhan SalehDepartment of Anesthesia and Critical Care Medicine, Faculty of Medicine, Cairo University, 01 elsarayah street, Elmanyal, Cairo, 11559, Egypt.
Maha IsmailDepartment of Anesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Hani El-HadiDepartment of Anesthesia and Critical Care Medicine, Faculty of Medicine, Cairo University, 01 elsarayah street, Elmanyal, Cairo, 11559, Egypt.
Cairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDeliberate hypotension is used to provide a bloodless field during functional endoscopic sinus surgery; however, the impact of controlled hypotension during anesthesia on peripheral tissue perfusion has not been extensively evaluated. The aim of this study was to compare the impact of nitroglycerin- versus labetalol-induced hypotension on peripheral perfusion.

methodsThe present randomized, double-blinded, controlled trial included adult patients undergoing endoscopic sinus surgery. Patients were allocated to one of two groups according to the drug received for induction of deliberate hypotension: nitroglycerin (n = 20) or labetalol (n = 20). Mean arterial pressure was maintained at 55-65 mmHg in both groups. Both study groups were compared according to pulse oximeter-derived peripheral perfusion index (primary outcome), serum lactate level, mean arterial pressure, heart rate, surgical field score, and intraoperative blood loss.

resultsForty patients were included in the final analysis. The nitroglycerin group exhibited a higher peripheral perfusion index at nearly all records (p < 0.0001) and lower postoperative serum lactate levels (1.3 ± 0.2 mmol/L vs. 1.7 ± 0.4 mmol/L; p = 0.001) than the labetalol group. The peripheral perfusion index was higher in the nitroglycerin group than at baseline at most intraoperative readings. The median surgical field score was modestly lower in the labetalol group than in the nitroglycerin group in the first 20 min (2 [interquartile range (IQR) 2-2.5] versus 1.5 [IQR 1-2]; p = 0.001). Both groups demonstrated comparable and acceptable surgical field scores in all subsequent readings.

conclusionNitroglycerin-induced deliberate hypotension was accompanied by higher peripheral perfusion index and lower serum lactate levels than labetalol-induced deliberate hypotension during sinus endoscopic surgery.

trial registrationThe study was registered at clinicaltrials registry system with trial number: NCT03809065. Registered at 19 January 2019. This study adheres to CONSORT guidelines.

Indexed as

AdultAntihypertensive AgentsDouble-Blind MethodEndoscopyFemaleHumansHypotension, ControlledLabetalolLactic AcidMaleNitroglycerinParanasal SinusesPerfusion IndexPilot ProjectsVasodilator AgentsYoung AdultAntihypertensive AgentsLabetalolLactic AcidNitroglycerinVasodilator AgentsDeliberate hypotensionLabetalolLactateNitroglycerinPeripheral perfusion

Identifiers

PMID32303182
PMCPMC7164266
OpenAlexW3017117187

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.