Evidence map›Paper›PMID 32303148›Full record

ArticleEpigenetics2020

The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene.

Andrea Leonardi, Nataliia Kovalchuk, Lei Yin, Lauren Endres, Sara Evke, Steven Nevins, Samuel Martin, Peter C Dedon, J Andres Melendez, Laura Van Winkle and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Epigenetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Structural Analysis of the AlkB Family in Poultry.Animals : an open access journal from MDPI · 2025
    Article
  4. tRNA modification enzyme-dependent redox homeostasis regulates synapse formation and memory.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Selenoproteins and the senescence-associated epitranscriptome.Experimental biology and medicine (Maywood, N.J.) · 2022
    Review
  9. Review
  10. Arsenite toxicity is regulated by queuine availability and oxidation-induced reprogramming of the human tRNA epitranscriptome.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Article
  12. The Effect of tRNAInternational journal of molecular sciences · 2021
    Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Andrea LeonardiDepartment of Nanoscale Science and Engineering, University at Albany , Albany, NY, USA.
Nataliia KovalchukCollege of Pharmacy, Department of Toxicology and Pharmacology, University of Arizona , Tucson, AZ, USA.
Lei YinCollege of Pharmacy, Department of Toxicology and Pharmacology, University of Arizona , Tucson, AZ, USA.
Lauren EndresCollege of Arts and Sciences, SUNY Polytechnic Institute , Utica, NY, USA.ORCID 0000-0002-7989-8671
Sara EvkeNanoscale Science Constellation, SUNY Polytechnic Institute , Albany, NY, USA.
Steven NevinsNanoscale Science Constellation, SUNY Polytechnic Institute , Albany, NY, USA.
Samuel MartinDepartment of Biological Sciences, University at Albany , Albany, NY, USA.
Peter C DedonDepartment of Biological Engineering, Massachusetts Institute of Technology , Cambridge, MA, USA.ORCID 0000-0003-0011-3067
J Andres MelendezThe RNA Institute, University at Albany , Albany, NY, USA.
Laura Van WinkleCenter for Health and the Environment, University of California Davis , Davis, CA, USA.
Qing-Yu ZhangCollege of Pharmacy, Department of Toxicology and Pharmacology, University of Arizona , Tucson, AZ, USA.
Xinxin DingCollege of Pharmacy, Department of Toxicology and Pharmacology, University of Arizona , Tucson, AZ, USA.
Thomas J BegleyThe RNA Institute, University at Albany , Albany, NY, USA.ORCID 0000-0002-5641-7644
University at Albany, State University of New York · USUniversity of Arizona · USSUNY Polytechnic Institute · USSingapore-MIT Alliance for Research and Technology · SGUniversity of California, Davis · US

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI George S Watts · 1994 to 2026
$36.7M
Reaction and Diffusion of NO in Biological SystemsP01CA026731 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI TANNENBAUM, STEVEN R · 1985 to 2018
$25.4M
Metabolic Mechanisms of Naphthalene Toxicity in LungR01ES020867 · NIEHS · WADSWORTH CENTER · PI Xinxin Ding, Laura S Van Winkle · 2013 to 2026
$6.4M
Translational regulation in exposure biology: Xenobiotic-induced reprograming oftRNA modifications and selective translation of codon-biased response genes in rat and humanmodelsR01ES026856 · NIEHS · SUNY POLYTECHNIC INSTITUTE · PI Thomas J Begley, Peter C Dedon · 2016 to 2026
$3.9M
Translational Control of ROS ManagementR01ES024615 · NIEHS · SUNY POLYTECHNIC INSTITUTE · PI BEGLEY, THOMAS J · 2014 to 2018
$1.8M
NCI NIH HHS P01 CA026731NIEHS NIH HHS P30 ES006694NIEHS NIH HHS R01 ES020867NIEHS NIH HHS R01 ES024615NIEHS NIH HHS R01 ES026856
6 · The paper itself

Abstract

The epitranscriptomic writer Alkylation Repair Homolog 8 (ALKBH8) is a transfer RNA (tRNA) methyltransferase that modifies the wobble uridine of selenocysteine tRNA to promote the specialized translation of selenoproteins. Using

Indexed as

Epigenesis, GeneticOxidative StressTranscriptomeAir PollutantsAlkB Homolog 8, tRNA MethyltransferaseAnimalsCytochrome P-450 Enzyme SystemDrug ResistanceLungMaleMiceMice, Inbred C57BLNaphthalenesRNA Processing, Post-TranscriptionalThioredoxin-Disulfide ReductaseAir PollutantsALKBH8 protein, mouseAlkB Homolog 8, tRNA MethyltransferaseCytochrome P-450 Enzyme SystemnaphthaleneNaphthalenesThioredoxin-Disulfide ReductaseALKBH8EpitranscriptomicsnaphthaleneRNA modificationselenoproteinstress responsetolerancetranslation

Identifiers

PMID32303148
PMCPMC7518688
OpenAlexW3017195313

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.