ArticleThe Science of the total environment2020
Prenatal phthalate, paraben, and phenol exposure and childhood allergic and respiratory outcomes: Evaluating exposure to chemical mixtures.
Article in The Science of the total environment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Maternal Phthalate Exposure and Allergic Diseases in Children: A Meta-Analysis and Network Toxicology.International journal of molecular sciences · 2025Pooled it
- A systematic review of the toxic potential of parabens in fish.Frontiers in toxicology · 2024Pooled it
- Bisphenol A exposure and abnormal glucose tolerance during pregnancy: systematic review and meta-analysis.Environmental science and pollution research international · 2021Pooled it
- Dimethyl phthalate induces cytotoxicity, oxidative stress, pro-inflammatory cytokine expression and fibronectin accumulation in A549 lung epithelial cells.Molecular biology reports · 2026Article
- Environmental Pollutants and Food Allergy: From Traditional Triggers to Emerging Hazards.Clinical reviews in allergy & immunology · 2026Review
- Prenatal Exposure to Phthalates, Bisphenols and Their Mixtures and Early Childhood Allergic Conditions and Asthma: Results from the APrON Cohort.International journal of environmental research and public health · 2025Article
- Early-life exposure to a mixture of phenols and respiratory health in preschool children.The European respiratory journal · 2025Article
- The impact of phthalates on asthma and chronic obstructive pulmonary disease: a comprehensive analysis based on network toxicology and molecular docking.Frontiers in pharmacology · 2025Article
- Exposure to heavy metals, bisphenol A, and phthalates: Implications for precocious or delayed puberty.PloS one · 2025Article
- Associations of prenatal exposure to phthalates and their mixture with lung function in Mexican children.Journal of hazardous materials · 2024Article
- Article
- Perioperative exposure to volatile organic compounds in neonates undergoing cardiac surgery.The Journal of thoracic and cardiovascular surgery · 2024Article
- Prenatal dietary exposure to mixtures of chemicals is associated with allergy or respiratory diseases in children in the ELFE nationwide cohort.Environmental health : a global access science source · 2024Article
- Association Between Urinary Phthalate Metabolites and Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study.International journal of chronic obstructive pulmonary disease · 2024Article
- Asthma and Environmental Exposures to Phenols, Polycyclic Aromatic Hydrocarbons, and Phthalates in Children.Current environmental health reports · 2023Article
- Personal Care and Household Cleaning Product Use among Pregnant Women and New Mothers during the COVID-19 Pandemic.International journal of environmental research and public health · 2022Article
- Childhood exposures to environmental chemicals and neurodevelopmental outcomes in congenital heart disease.PloS one · 2022Article
- Variability of Urinary Concentrations of Phenols, Parabens, and Triclocarban during Pregnancy in First Morning Voids and Pooled Samples.Environmental science & technology · 2021Article
- Performance of urine, blood, and integrated metal biomarkers in relation to birth outcomes in a mixture setting.Environmental research · 2021Article
- Temporal Trends of Phenol, Paraben, and Triclocarban Exposure in California Pregnant Women during 2007-2014.Environmental science & technology · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundChemicals found in personal care products and plastics have been associated with asthma, allergies, and lung function, but methods to address real life exposure to mixtures of these chemicals have not been applied to these associations.
methodsWe quantified urinary concentrations of eleven phthalate metabolites, four parabens, and five other phenols in mothers twice during pregnancy and assessed probable asthma, aeroallergies, and lung function in their age seven children. We implemented Bayesian Profile Regression (BPR) to cluster women by their exposures to these chemicals and tested the clusters for differences in outcome measurements. We used Bayesian Kernel Machine Regression (BKMR) to fit biomarkers into one model as joint independent variables.
resultsBPR clustered women into seven groups characterized by patterns of personal care product and plastic use, though there were no significant differences in outcomes across clusters. BKMR showed that monocarboxyisooctyl phthalate and 2,4-dichlorophenol were associated with probable asthma (predicted probability of probable asthma per IQR of biomarker z-score (standard deviation) = 0.08 (0.09) and 0.11 (0.12), respectively) and poorer lung function (predicted probability per IQR = -0.07 (0.05) and -0.07 (0.06), respectively), and that mono(3-carboxypropyl) phthalate and bisphenol A were associated with aeroallergies (predicted probability per IQR = 0.13 (0.09) and 0.11 (0.08), respectively). Several biomarkers demonstrated positive additive effects on other associations.
conclusionsBPR and BKMR are useful tools to evaluate associations of biomarker concentrations within a mixture of exposure and should supplement single-chemical regression models when data allow.
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