Evidence map›Paper›PMID 32302519›Full record

ArticleTherapeutic hypothermia and temperature management2021

Additive Protective Effects of Delayed Mild Therapeutic Hypothermia and Antioxidants on PC12 Cells Exposed to Oxidative Stress.

Jayanti Singh, John Barrett, Rachele Sangaletti, W Dalton Dietrich, Suhrud M Rajguru

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Therapeutic hypothermia and temperature management, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06729632 (Non-Invasive System to Deliver Therapeutic Hypothermia for Protection Against Noise-Induced Hearing Loss), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06729632 narecruitingnot on this mapstarted 2024, after this paper: background citation

Non-Invasive System to Deliver Therapeutic Hypothermia for Protection Against Noise-Induced Hearing Loss

TypeinterventionalSponsorRestorear Devices LLCRan2024 to 2027Enrolled116ConditionsNoise Exposure, Noise-induced Hearing Loss, Noise, Adverse EffectArmsCold pack-delivered mild therapeutic hypothermia
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jayanti SinghDepartment of Otolaryngology, University of Miami, Miami, Florida, USA.
John BarrettDepartment of Physiology and Biophysics, University of Miami, Miami, Florida, USA.
Rachele SangalettiDepartment of Otolaryngology, University of Miami, Miami, Florida, USA.
W Dalton DietrichDepartment of Biomedical Engineering, University of Miami, Miami, Florida, USA.
Suhrud M RajguruDepartment of Otolaryngology, University of Miami, Miami, Florida, USA.
University of Miami · US

Funding

Miami Clinical and Translational Science InstituteUL1TR002736 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, KOBETZ, ERIN N · 2018 to 2022
$23.2M
Miami Clinical and Translational Science InstituteUL1TR000460 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SACCO, RALPH L. · 2012 to 2016
$16.9M
Pulsed infrared excitability of inner ear: molecular mechanisms and therapeuticsR01DC013798 · NIDCD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RAJGURU, SUHRUD M. · 2015 to 2019
$1.9M
6 · The paper itself

Abstract

Mild therapeutic hypothermia is protective against several cellular stresses, but the mechanisms underlying this protection are not completely resolved. In the present study, we used an

Indexed as

AntioxidantsHypothermia, InducedAnimalsApoptosisHydrogen PeroxideOxidative StressPC12 CellsRatsAntioxidantsHydrogen Peroxideantioxidantscell viabilityhypothermiaoxidative stressPC12reactive oxygenROStherapeutic hypothermia

Identifiers

PMID32302519
PMCPMC8215413
OpenAlexW3016523564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.