ArticlePloS one2020
Resting state networks of the canine brain under sevoflurane anaesthesia.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Systematic Review: Anaesthetic Protocols and Management as Confounders in Rodent Blood Oxygen Level Dependent Functional Magnetic Resonance Imaging (BOLD fMRI)-Part A: Effects of Changes in Physiological Parameters.Frontiers in neuroscience · 2020Pooled it
- Investigating gray matter volumes in idiopathic epileptic Border Collies and Greater Swiss Mountain Dogs using voxel-based morphometry.Frontiers in veterinary science · 2026Article
- Preliminary Findings on Low-Dose 1cp-LSD for Canine Anxiety: Exploring the Role of Owner Neuroticism and Psychopathology.Veterinary sciences · 2025Article
- Flow augmentation therapies preserve brain network integrity and hemodynamics in a canine permanent occlusion model.Scientific reports · 2024Article
- Two Separate Brain Networks for Predicting Trainability and Tracking Training-Related Plasticity in Working Dogs.Animals : an open access journal from MDPI · 2024Article
- Diffusion tensor imaging for detecting biomarkers of idiopathic epilepsy in dogs.Frontiers in veterinary science · 2024Review
- Magnetic resonance imaging in canine idiopathic epilepsy: a mini-review.Frontiers in veterinary science · 2024Review
- Structural connectome alterations in anxious dogs: a DTI-based study.Scientific reports · 2023Article
- Central nodes of canine functional brain networks are concentrated in the cingulate gyrus.Brain structure & function · 2023Article
- Diffusion tensor-based analysis of white matter in dogs with idiopathic epilepsy.Frontiers in veterinary science · 2023Article
- Increased resting state connectivity in the anterior default mode network of idiopathic epileptic dogs.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resting-state functional Magnetic Resonance Imaging (rs-fMRI) has become an established technique in humans and reliably determines several resting state networks (RSNs) simultaneously. Limited data exist about RSN in dogs. The aim of this study was to investigate the RSNs in 10 healthy beagle dogs using a 3 tesla MRI scanner and subsequently perform group-level independent component analysis (ICA) to identify functionally connected brain networks. Rs-fMRI sequences were performed under steady state sevoflurane inhalation anaesthesia. Anaesthetic depth was titrated to the minimum level needed for immobilisation and mechanical ventilation of the patient. This required a sevoflurane MAC between 0.8 to 1.2. Group-level ICA dimensionality of 20 components revealed distributed sensory, motor and higher-order networks in the dogs' brain. We identified in total 7 RSNs (default mode, primary and higher order visual, auditory, two putative motor-somatosensory and one putative somatosensory), which are common to other mammals including humans. Identified RSN are remarkably similar to those identified in awake dogs. This study proves the feasibility of rs-fMRI in anesthetized dogs and describes several RSNs, which may set the basis for investigating pathophysiological characteristics of various canine brain diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.