ArticleThe Journal of clinical endocrinology and metabolism2020
Contributions of Prenatal Exposures and Child Lifestyle to Insulin Sensitivity.
Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 4 citations in OpenAlex.
- Associations between maternal and offspring glucose metabolism: a 9-year follow-up of a randomised controlled trial.Frontiers in endocrinology · 2023Trial
- Prenatal and postnatal maternal obesity and their associations with child nutrition and weight outcomes: A systematic review.Reviews in endocrine & metabolic disorders · 2026Review
- Maternal Serum Polyols and Its Link to Gestational Diabetes Mellitus: A Population-Based Nested Case-Control Study.The Journal of clinical endocrinology and metabolism · 2024Article
- Associations Between Sleep and Metabolic Outcomes in Preadolescent Children.Journal of the Endocrine Society · 2022Article
- Associations Between Exposure to Gestational Diabetes Mellitus In Utero and Daily Energy Intake, Brain Responses to Food Cues, and Adiposity in Children.Diabetes care · 2021Article
- Contributions of Prenatal Exposures and Child Lifestyle to Insulin Sensitivity.The Journal of clinical endocrinology and metabolism · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
contextPrenatal exposures and lifestyle factors are important for metabolic health.
objectiveDetermine how prenatal exposures to maternal obesity and/or gestational diabetes mellitus (GDM) and childhood lifestyle factors independently contribute to child insulin sensitivity. DESIGN AND
participantsNinety children aged 7 to 11 years (56% girls, 60% exposed to GDM), born at Kaiser-Permanente Southern California, completed an oral glucose tolerance test (OGTT) as part of the BrainChild Study. Matsuda insulin sensitivity index (ISI) was used to estimate insulin sensitivity. Participants completed two 24-hour dietary recalls, and daily energy intake (EI), dietary added sugar, and total sugar were calculated. The 3-day physical activity recall determined the average minutes per day of moderate to vigorous physical activity (MVPA) and the average minutes per day spent sedentary. Maternal prepregnancy body mass index (BMI) and GDM status were extracted from electronic medical records.
main outcome measureMatsuda-ISI.
resultsLinear regression showed that children who spent more time in MVPA had better ISI (β = 0.33; P = 0.001), and results remained after adjustment for maternal prepregnancy BMI, GDM exposure, child age, sex, daily EI, dietary added sugar (β = 0.34; P = 0.001), and further adjustment for child adiposity (β = 0.29; P = 0.001). Time spent sedentary, maternal prepregnancy BMI, GDM exposure, dietary added sugar, total sugar, and EI were not associated with ISI.
conclusionsPhysical activity was the only predictor of ISI at this age, suggesting that engaging in physical activity during childhood is beneficial for insulin sensitivity and may ameliorate future risk for metabolic disease.
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