Evidence map›Paper›PMID 32301993›Full record

ArticleSocial cognitive and affective neuroscience2020

Affective brain patterns as multivariate neural correlates of cardiovascular disease risk.

Peter J Gianaros, Thomas E Kraynak, Dora C-H Kuan, James J Gross, Kateri McRae, Ahmad R Hariri, Stephen B Manuck, Javier Rasero, Timothy D Verstynen

Open access · goldAbstract read
In one paragraph

Article in Social cognitive and affective neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 28 citations in OpenAlex.

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  9. Psychological stress and the longitudinal progression of subclinical atherosclerosis.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024
    Article
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  14. Limits of decoding mental states with fMRI.Cortex; a journal devoted to the study of the nervous system and behavior · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Peter J GianarosDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Thomas E KraynakDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Dora C-H KuanDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
James J GrossDepartment of Psychology, Stanford University, Stanford, CA, 94305, USA.
Kateri McRaeDepartment of Psychology, University of Denver, Denver, CO, 80208, USA.
Ahmad R HaririDepartment of Psychology and Neuroscience, Duke University, Durham, NC, 27708, USA.
Stephen B ManuckCenter for the Neural Basis of Cognition, University of Pittsburgh and Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Javier RaseroDepartment of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Timothy D VerstynenCenter for the Neural Basis of Cognition, University of Pittsburgh and Carnegie Mellon University, Pittsburgh, PA 15213, USA.
University of Pittsburgh · USCarnegie Mellon University · USDuke University · USStanford University · USUniversity of Denver · US

Funding

Substrates of Threat and Reward Sensitivity and CVD RiskP01HL040962 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 1988 to 2022
$31.1M
6 · The paper itself

Abstract

This study tested whether brain activity patterns evoked by affective stimuli relate to individual differences in an indicator of pre-clinical atherosclerosis: carotid artery intima-media thickness (CA-IMT). Adults (aged 30-54 years) completed functional magnetic resonance imaging (fMRI) tasks that involved viewing three sets of affective stimuli. Two sets included facial expressions of emotion, and one set included neutral and unpleasant images from the International Affective Picture System (IAPS). Cross-validated, multivariate and machine learning models showed that individual differences in CA-IMT were partially predicted by brain activity patterns evoked by unpleasant IAPS images, even after accounting for age, sex and known cardiovascular disease risk factors. CA-IMT was also predicted by brain activity patterns evoked by angry and fearful faces from one of the two stimulus sets of facial expressions, but this predictive association did not persist after accounting for known cardiovascular risk factors. The reliability (internal consistency) of brain activity patterns evoked by affective stimuli may have constrained their prediction of CA-IMT. Distributed brain activity patterns could comprise affective neural correlates of pre-clinical atherosclerosis; however, the interpretation of such correlates may depend on their psychometric properties, as well as the influence of other cardiovascular risk factors and specific affective cues.

Indexed as

IndividualityAdultAtherosclerosisBrainBrain MappingCardiovascular DiseasesCarotid Intima-Media ThicknessCuesEmotionsFacial ExpressionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedReproducibility of Resultsaffectcardiovascular disease riskemotionfMRImachine learning

Identifiers

PMID32301993
PMCPMC7657455
OpenAlexW3016677355

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.