ArticleEuropean heart journal. Cardiovascular Imaging2021
Impaired myocardial reserve underlies reduced exercise capacity and heart rate recovery in preterm-born young adults.
Article in European heart journal. Cardiovascular Imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Physiological responses to exercise in survivors of preterm birth: a meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Influence of Preterm Birth and Low Birthweight on Physical Fitness: A Systematic Review, Meta-Analysis, and Meta-Regression.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Aerobic Exercise Training Response in Preterm-Born Young Adults with Elevated Blood Pressure and Stage 1 Hypertension: A Randomized Clinical Trial.American journal of respiratory and critical care medicine · 2023Trial
- Clinical study: Cardiovascular outcomes after a 14-week exercise intervention in young adults born preterm.Pediatric research · 2026Article
- Cardio-Metabolic Risk in Adults Born Preterm: A Narrative Review.Journal of clinical medicine · 2025Review
- Central and Peripheral Mechanisms of Low Exercise Capacity in Prematurely Born Adults.Comprehensive physiology · 2025Article
- Dose-related cardiac outcomes in response to postnatal dexamethasone treatment in premature lambs.Anatomical record (Hoboken, N.J. : 2007) · 2025Article
- Smaller Left Ventricular Size But Preserved Function in Adolescents and Adults Born Preterm.Journal of the American Heart Association · 2024Article
- Seeing pulmonary hypertension through a paediatric lens: a viewpoint.The European respiratory journal · 2024Article
- Heart Rate and Heart Rate Variability in Healthy Preterm-Born Young Adults and Association with Vitamin D: A Wearable Device Assessment.Journal of clinical medicine · 2023Article
- Dysanapsis as a Determinant of Lung Function in Development and Disease.American journal of respiratory and critical care medicine · 2023Article
- Consequences of Preterm Birth: Knowns, Unknowns, and Barriers to Advancing Cardiopulmonary Health.Integrative and comparative biology · 2023Article
- Exercise Capacity in Very Low Birth Weight Adults: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2023Review
- Impact of premature birth on cardiopulmonary function in later life.European journal of pediatrics · 2023Article
- Preterm birth and exercise capacity: what do we currently know?Frontiers in pediatrics · 2023Review
- Exercise and hypoxia unmask pulmonary vascular disease and right ventricular dysfunction in a 10- to 12-week-old swine model of neonatal oxidative injury.The Journal of physiology · 2022Article
- Understanding the preterm human heart: What do we know so far?Anatomical record (Hoboken, N.J. : 2007) · 2022Review
- Acute and chronic cardiac adaptations in adults born preterm.Experimental physiology · 2022Review
- Physiological aspects of cardiopulmonary dysanapsis on exercise in adults born preterm.The Journal of physiology · 2022Review
- Decreased ventricular size and mass mediate the reduced exercise capacity in adolescents and adults born premature.Early human development · 2021Article
Corrections and comments
- Erratum issuedErratum.2020
Authors and funding
12 authors at 2 institutions in 5 countries.
Funding
Abstract
aimsWe tested the hypothesis that the known reduction in myocardial functional reserve in preterm-born young adults is an independent predictor of exercise capacity (peak VO2) and heart rate recovery (HRR). METHODS AND
resultsWe recruited 101 normotensive young adults (n = 47 born preterm; 32.8 ± 3.2 weeks' gestation and n = 54 term-born controls). Peak VO2 was determined by cardiopulmonary exercise testing (CPET), and lung function assessed using spirometry. Percentage predicted values were then calculated. HRR was defined as the decrease from peak HR to 1 min (HRR1) and 2 min of recovery (HRR2). Four-chamber echocardiography views were acquired at rest and exercise at 40% and 60% of CPET peak power. Change in left ventricular ejection fraction from rest to each work intensity was calculated (EFΔ40% and EFΔ60%) to estimate myocardial functional reserve. Peak VO2 and per cent of predicted peak VO2 were lower in preterm-born young adults compared with controls (33.6 ± 8.6 vs. 40.1 ± 9.0 mL/kg/min, P = 0.003 and 94% ± 20% vs. 108% ± 25%, P = 0.001). HRR1 was similar between groups. HRR2 decreased less in preterm-born young adults compared with controls (-36 ± 13 vs. -43 ± 11 b.p.m., P = 0.039). In young adults born preterm, but not in controls, EFΔ40% and EFΔ60% correlated with per cent of predicted peak VO2 (r2 = 0.430, P = 0.015 and r2 = 0.345, P = 0.021). Similarly, EFΔ60% correlated with HRR1 and HRR2 only in those born preterm (r2 = 0.611, P = 0.002 and r2 = 0.663, P = 0.001).
conclusionsImpaired myocardial functional reserve underlies reductions in peak VO2 and HRR in young adults born moderately preterm. Peak VO2 and HRR may aid risk stratification and treatment monitoring in this population.
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