Evidence map›Paper›PMID 32301548›Full record

ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2020

Parallel studies of mucosal immunity in the reproductive and gastrointestinal mucosa of HIV-infected women.

Uma Shanmugasundaram, J William Critchfield, Linda C Giudice, Karen Smith-McCune, Ruth M Greenblatt, Barbara L Shacklett

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. T-Cell Biology in the Female Reproductive Tract: Relevance to HIV Infection.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Uma ShanmugasundaramDepartment of Medical Microbiology and Immunology, University of California, Davis, CA, USA.
J William CritchfieldDepartment of Medical Microbiology and Immunology, University of California, Davis, CA, USA.
Linda C GiudiceDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA, USA.
Karen Smith-McCuneDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA, USA.
Ruth M GreenblattDepartment of Clinical Pharmacy, University of California, San Francisco, CA, USA.
Barbara L ShacklettDepartment of Medical Microbiology and Immunology, University of California, Davis, CA, USA.ORCID 0000-0002-7067-732X
University of California Davis Medical Center · USUniversity of California, San Francisco · US

Funding

WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Viral and Host Factors Promoting Male-to-Female Transmission of HIVP01AI083050 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI GREENE, WARNER C. · 2009 to 2013
$10.1M
HIV-Specific T Cell Responses in Rectal MucosaR01AI057020 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI SHACKLETT, BARBARA L. · 2003 to 2016
$6.2M
UC Davis Shared Astrios Cell SorterS10OD018223 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SHACKLETT, BARBARA L. · 2015 to 2015
$555k
Shared LSRII Cytometer Equipment Application - UC Davis Stem Cell ProgramS10RR026825 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NOLTA, JAN A. · 2010 to 2010
$500k
CELL SORTER FOR AN OPTICAL BIOLOGY FACILITYS10RR012964 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI LUCIW, PAUL A · 1998 to 1998
–
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR012088 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI CURRY, FITZ-ROY E · 1996 to 1996
–
National Institute of Allergy and Infectious Diseases P01-AI083050NCI NIH HHS P30-CA0933730NCRR NIH HHS C06 RR012088NCRR NIH HHS S10-RR012964NCRR NIH HHS S10 RR026825NIAID NIH HHS P01 AI083050NIAID NIH HHS R01 AI057020NIAID NIH HHS U01 AI034989NIH HHS S10 OD018223
6 · The paper itself

Abstract

problemThe effects of HIV on the gastrointestinal tract (GIT), including CD4 depletion, epithelial disruption, and collagen deposition, are well documented and only partially reversed by combination antiretroviral therapy (cART). However, the effects of HIV on the female reproductive tract (FRT) are poorly understood, and most studies have focused on ectocervix and vagina without assessing the upper tract. Here, we investigated CD4 METHOD OF STUDY: Mucosal samples and blood were obtained from 18 women: four who were HIV-positive and not on cART for at least 3 years prior to sampling, including two natural controllers (viral load [VL] undetectable and CD4 >350); nine women on cART with low to undetectable VL; and five HIV-uninfected women. Mucosal samples included terminal ileum, sigmoid colon, endocervical cytobrush, endocervical curettage, and endometrial biopsy. T-cell frequency, phenotypes, and HIV-specific T-cell responses were analyzed by multiparameter flow cytometry.

resultsT-cell activation, measured by CD38/HLA-DR co-expression, remained significantly elevated in endometrium following cART, but was lower in gastrointestinal tissues. HIV-specific CD8

conclusionOur findings reveal differences in CD4

Indexed as

AdultAntiretroviral Therapy, Highly ActiveCD4-Positive T-LymphocytesCells, CulturedFemaleGenitalia, FemaleHIV-1HIV InfectionsHumansImmunity, MucosalImmunophenotypingIntestinal MucosaLymphocyte ActivationMiddle AgedOrgan SpecificityCTLendocervixendometriumGALTHIVMALTT-cell

Identifiers

PMID32301548
PMCPMC7302888
OpenAlexW3016604218

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.