Evidence map›Paper›PMID 32301482›Full record

ArticleEndocrinology2020

Androgen Action in Adipose Tissue and the Brain are Key Mediators in the Development of PCOS Traits in a Mouse Model.

Madeleine J Cox, Melissa C Edwards, Valentina Rodriguez Paris, Ali Aflatounian, William L Ledger, Robert B Gilchrist, Vasantha Padmanabhan, David J Handelsman, Kirsty A Walters

Open access · bronzeAbstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 54 citations in OpenAlex.

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  14. Androgen signalling in the ovaries and endometrium.Molecular human reproduction · 2023
    Review
  15. Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome.International journal of molecular sciences · 2023
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Madeleine J CoxFertility and Research Centre, School of Women's & Children's Health, University of New South Wales, Sydney, Australia.
Melissa C EdwardsFertility and Research Centre, School of Women's & Children's Health, University of New South Wales, Sydney, Australia.
Valentina Rodriguez ParisFertility and Research Centre, School of Women's & Children's Health, University of New South Wales, Sydney, Australia.
Ali AflatounianFertility and Research Centre, School of Women's & Children's Health, University of New South Wales, Sydney, Australia.
William L LedgerFertility and Research Centre, School of Women's & Children's Health, University of New South Wales, Sydney, Australia.
Robert B GilchristFertility and Research Centre, School of Women's & Children's Health, University of New South Wales, Sydney, Australia.
Vasantha PadmanabhanDepartment of Pediatrics, University of Michigan, Ann Arbor, Michigan.
David J HandelsmanAndrology Laboratory, ANZAC Research Institute, University of Sydney, Sydney, Australia.
Kirsty A WaltersFertility and Research Centre, School of Women's & Children's Health, University of New South Wales, Sydney, Australia.
UNSW Sydney · AUThe University of Sydney · AUUniversity of Michigan · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) is a complex disorder characterized by endocrine, reproductive, and metabolic abnormalities. Despite PCOS being the most common endocrinopathy affecting women of reproductive age, the etiology of PCOS is poorly understood, so there is no cure and symptomatic treatment is suboptimal. Hyperandrogenism is the most consistent feature observed in PCOS patients, and recently aberrant neuroendocrine signaling and adipose tissue function have been proposed as playing a role in the development of PCOS. To investigate the role of adipose tissue and the brain as key sites for androgen receptor (AR)-mediated development of PCOS, we combined a white and brown adipose and brain-specific AR knockout (AdBARKO) mouse model with a dihydrotestosterone (DHT)-induced mouse model of PCOS. As expected, in wildtype (WT) control females, DHT exposure induced the reproductive PCOS traits of cycle irregularity, ovulatory dysfunction, and reduced follicle health, whereas in AdBARKO females, DHT did not produce the reproductive features of PCOS. The metabolic PCOS characteristics of increased adiposity, adipocyte hypertrophy, and hepatic steatosis induced by DHT in WT females were not evident in DHT-treated AdBARKO females, which displayed normal white adipose tissue weight and no adipocyte hypertrophy or liver steatosis. Dihydrotestosterone treatment induced increased fasting glucose levels in both WT and AdBARKO females. These findings demonstrate that adipose tissue and the brain are key loci of androgen-mediated actions involved in the developmental origins of PCOS. These data support targeting adipocyte and neuroendocrine AR-driven pathways in the future development of novel therapeutic strategies for PCOS.

Indexed as

Disease Models, AnimalAdipose TissueAnimalsBrainDihydrotestosteroneFemaleMice, KnockoutPolycystic Ovary SyndromeReceptors, AndrogenDihydrotestosteroneReceptors, Androgenadipocyteanimal modelbrainhyperandrogenismpolycystic ovary syndrome (PCOS)

Identifiers

PMID32301482
OpenAlexW3016432471

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.