Evidence map›Paper›PMID 32301336›Full record

ArticleCirculation. Heart failure2020

Epidemiology and Outcomes of Acute Decompensated Heart Failure in Children.

Javier J Lasa, Michael Gaies, Lauren Bush, Wenying Zhang, Mousumi Banerjee, Jeffrey A Alten, Ryan J Butts, Antonio G Cabrera, Paul A Checchia, Justin Elhoff and 5 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 57 citations in OpenAlex.

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  9. Management of Pediatric Heart Failure.Korean circulation journal · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Javier J LasaDivision of Critical Care Medicine (J.J.L., P.A.C., J.E., L.S.S.), Texas Children's Hospital, Baylor College of Medicine, Houston.
Michael GaiesDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor (M.G., K.S.).
Lauren BushPC Data Coordinating Center, Michigan Congenital Heart Outcomes Research and Discovery Unit, University of Michigan, Ann Arbor (L.B., W.Z.).
Wenying ZhangPC Data Coordinating Center, Michigan Congenital Heart Outcomes Research and Discovery Unit, University of Michigan, Ann Arbor (L.B., W.Z.).
Mousumi BanerjeeDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor (M.B.).
Jeffrey A AltenDepartment of Pediatrics, Heart Institute, Cincinnati Children's Hospital Medical Center, OH (J.A.A., A.L.).
Ryan J ButtsUT Southwestern Department of Pediatrics, Division of Cardiology, UT Southwestern Medical Center, Dallas, TX (R.J.B.).
Antonio G CabreraDivision of Cardiology (J.J.L., A.G.C., J.F.P.), Texas Children's Hospital, Baylor College of Medicine, Houston.
Paul A ChecchiaDivision of Critical Care Medicine (J.J.L., P.A.C., J.E., L.S.S.), Texas Children's Hospital, Baylor College of Medicine, Houston.
Justin ElhoffDivision of Critical Care Medicine (J.J.L., P.A.C., J.E., L.S.S.), Texas Children's Hospital, Baylor College of Medicine, Houston.
Angela LortsDepartment of Pediatrics, Heart Institute, Cincinnati Children's Hospital Medical Center, OH (J.A.A., A.L.).
Joseph W RossanoDivision of Cardiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine (J.W.R.).
Kurt SchumacherDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor (M.G., K.S.).
Lara S ShekerdemianDivision of Critical Care Medicine (J.J.L., P.A.C., J.E., L.S.S.), Texas Children's Hospital, Baylor College of Medicine, Houston.
Jack F PriceDivision of Cardiology (J.J.L., A.G.C., J.F.P.), Texas Children's Hospital, Baylor College of Medicine, Houston.
World Wide Web Consortium · US

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Explaining Variation in Mortality after Pediatric Cardiac SurgeryK08HL116639 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GAIES, MICHAEL · 2014 to 2018
$767k
NCATS NIH HHS UL1 TR002240NHLBI NIH HHS K08 HL116639
6 · The paper itself

Abstract

backgroundAcute decompensated heart failure (ADHF) is a highly morbid condition among adults. Little is known about outcomes in children with ADHF. We analyzed the Pediatric Cardiac Critical Care Consortium registry to determine the epidemiology, contemporary treatments, and predictors of mortality in critically ill children with ADHF.

methodsCardiac intensive care unit (CICU) patients ≤18 years of age meeting Pediatric Cardiac Critical Care Consortium criteria for ADHF were included. ADHF was defined as systolic or diastolic dysfunction requiring continuous vasoactive or diuretic infusion, respiratory support, or mechanical circulatory support. Demographics, diagnosis, therapies, complications, and mortality are described for the cohort. Predictors of CICU mortality were identified using logistic regression.

resultsAmong 26 294 consecutive admissions (23 centers), 1494 (6%) met criteria for analysis. Median age was 0.93 years (interquartile range, 0.1-9.3 years). Patients with congenital heart disease (CHD) comprised 57% of the cohort. Common therapies included the following: vasoactive infusions (88%), central venous catheters (86%), mechanical ventilation (59%), and high flow nasal cannula (46%). Common complications were arrhythmias (19%), cardiac arrest (10%), sepsis (7%), and acute renal failure requiring dialysis (3%). Median length of CICU stay was 7.9 days (interquartile range, 3-18 days) and the CICU readmission rate was 22%. Overall, CICU mortality was 15% although higher for patients with CHD versus non-CHD (19% versus 11%;

conclusionsADHF in children is characterized by comorbidities, high mortality rates, and frequent readmission, especially among patients with CHD. Opportunities exist to determine best practices around appropriate use of mechanical support, cardiac arrest prevention, and optimal heart transplantation candidacy to improve outcomes for these patients.

Indexed as

AdolescentAge FactorsAge of OnsetChildChild, PreschoolComorbidityCritical IllnessFemaleHeart Defects, CongenitalHeart FailureHospital MortalityHumansInfantInfant, NewbornMaleNorth Americacritical caredemographyheart failurepediatricsquality of care

Identifiers

PMID32301336
PMCPMC7169981
OpenAlexW3016453346

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.