Evidence map›Paper›PMID 32301185›Full record

ArticleMagnetic resonance in medicine2020

Accelerating GluCEST imaging using deep learning for B

Yiran Li, Danfeng Xie, Abigail Cember, Ravi Prakash Reddy Nanga, Hanlu Yang, Dushyant Kumar, Hari Hariharan, Li Bai, John A Detre, Ravinder Reddy and 1 more

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  3. Transformer Enabled Half Z‑spectrum Sampling BChemical & biomedical imaging · 2026
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  18. Deep Learning and Its Application to Function Approximation for MR in Medicine: An Overview.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022
    Review
  19. Review
  20. BTomography (Ann Arbor, Mich.) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Yiran LiDepartment of Electrical and Computer Engineering, Temple University, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-5502-2106
Danfeng XieDepartment of Electrical and Computer Engineering, Temple University, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-3475-206X
Abigail CemberDepartment of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-4747-6079
Ravi Prakash Reddy NangaDepartment of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Hanlu YangDepartment of Electrical and Computer Engineering, Temple University, Philadelphia, Pennsylvania, USA.
Dushyant KumarDepartment of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-1617-6399
Hari HariharanDepartment of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Li BaiDepartment of Electrical and Computer Engineering, Temple University, Philadelphia, Pennsylvania, USA.
John A DetreDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Ravinder ReddyDepartment of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Ze WangDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-8339-5567
University of Pennsylvania · USTemple University · USUniversity of Maryland, Baltimore · US

Funding

Training and DisseminationP41EB015893 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2012 to 2019
$11.3M
Multimodal Imaging of Progesterone/Neurosteroid Effects in Nicotine AddictionR01DA037289 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI EPPERSON, C. NEILL · 2015 to 2019
$3.3M
Assessing ASL CBF as a biomarker for early Alzheimer's disease detection and disease progressionR01AG060054 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI WANG, ZE · 2019 to 2021
$1.7M
NIA NIH HHS R01 AG060054NIBIB NIH HHS P41 EB015893NIDA NIH HHS R01 DA037289
6 · The paper itself

Abstract

purposeGlutamate weighted Chemical Exchange Saturation Transfer (GluCEST) MRI is a noninvasive technique for mapping parenchymal glutamate in the brain. Because of the sensitivity to field (B

methodsB

resultsAll DL-based methods outperformed the "traditional" method visually and quantitatively. The wide activation blocks-based method showed the highest performance in terms of Structural Similarity Index (SSIM) and peak signal-to-noise ratio (PSNR), which were 0.84 and 25dB respectively. SNR increases in regions of interest were over 8dB.

conclusionWe demonstrated that the new DL-based method can reduce the entire GluCEST imaging time by ˜50% and yield higher SNR than current state-of-the-art.

Indexed as

Deep LearningGlutamic AcidBrainBrain MappingHumansMagnetic Resonance ImagingGlutamic Aciddeep learningdeep residual networkGluCESTwide activation

Identifiers

PMID32301185
PMCPMC8082274
OpenAlexW3016749298

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.