Evidence map›Paper›PMID 32301032›Full record

ArticleMolecular diversity2021

Synthesis, β-glucuronidase inhibition and molecular docking studies of cyano-substituted bisindole hydrazone hybrids.

Obaidurahman Abid, Syahrul Imran, Muhammad Taha, Nor Hadiani Ismail, Waqas Jamil, Syed Muhammad Kashif, Khalid Mohammed Khan, Juliana Yusoff

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Obaidurahman AbidAtta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor, Malaysia.
Syahrul ImranAtta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor, Malaysia. imran@isiswa.uitm.edu.my.ORCID http://orcid.org/0000-0001-7802-7359
Muhammad TahaDepartment of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia. taha_hej@yahoo.com.
Nor Hadiani IsmailAtta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor, Malaysia.
Waqas JamilInstitute of Advanced Research Studies in Chemical Sciences, University of Sindh Jamshoro, Hyderabad, 76080, Pakistan.
Syed Muhammad KashifInstitute of Advanced Research Studies in Chemical Sciences, University of Sindh Jamshoro, Hyderabad, 76080, Pakistan.
Khalid Mohammed KhanH. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Juliana YusoffAtta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor, Malaysia.
Universiti Teknologi MARA · MYUniversity of Sindh · PKImam Abdulrahman Bin Faisal University · SANangarhar University · AFUniversiti Teknologi MARA System · MYUniversity of Karachi · PK

Funding

Kementerian Pendidikan Malaysia 600-IRMI/FRGS 5/3 (111/2019)Kementerian Pendidikan Malaysia 600-RMI/FRGS 5/3 (0065/2016)Universiti Teknologi MARA (MY) 600-IRMI/PERDANA 5/3 BESTARI (041/2018)
6 · The paper itself

Abstract

The β-glucuronidase, a lysosomal enzyme, catalyzes the cleavage of glucuronosyl-O-bonds. Its inhibitors play a significant role in different medicinal therapies as they cause a decrease in carcinogen-induced colonic tumors by reducing the level of toxic substances present in the intestine. Among those inhibitors, bisindole derivatives had displayed promising β-glucuronidase inhibition activity. In the current study, hydrazone derivatives of bisindolymethane (1-30) were synthesized and evaluated for in vitro β-glucuronidase inhibitory activity. Twenty-eight analogs demonstrated better activity (IC

Indexed as

GlycoproteinsHydrazonesIndolesGlucuronidaseMolecular Docking Simulationbeta-glucuronidase inhibitorGlucuronidaseGlycoproteinsHydrazonesIndolesBisindoleHydrazoneMolecular dockingSynthesisβ-Glucuronidase inhibition

Identifiers

PMID32301032
OpenAlexW3017130289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.