ArticleComputational and mathematical methods in medicine2020
Heredity Indexes for Estimating Heritability Using Known and Unknown Family Data Based on the Model of Polygenic Inheritance.
Article in Computational and mathematical methods in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Bayesian Modeling of COVID-19 to Classify the Infection and Death Rates in a Specific Duration: The Case of Algerian Provinces.International journal of environmental research and public health · 2022Article
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Abstract
objectiveTo establish a model for estimating genetic risk using known and unknown family data.
methodsFour simulated datasets were generated for four paternal and maternal chromosomes. The simulated data for children were generated from the parental data according to the Mendelian law. The correlation coefficient between the children's and paternal data was calculated, and 2
resultsDifferent actual pedigree data (lunula and holding a hammer in the right or left hand) were successfully used to verify the accuracy of the model. The genetic risk was estimated according to the incidence in a population using a lookup table.
conclusionOur findings indicate the reliability of the model based on the fact that the multigene effect constitutes the normal distribution. Thus, this model can be used for comprehensive analysis of the influence of genetic and nongenetic factors on the genetic phenotype and to estimate genetic risk using known and unknown family data.
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