Evidence map›Paper›PMID 32300344›Full record

ArticleFrontiers in immunology2020

TCR Dependent Metabolic Programming Regulates Autocrine IL-4 Production Resulting in Self-Tuning of the CD8

Kali F Crofts, Beth C Holbrook, David R Soto-Pantoja, David A Ornelles, Martha A Alexander-Miller

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Cell Therapy with Human Reprogrammed CD8International journal of molecular sciences · 2022
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kali F CroftsDepartment of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Beth C HolbrookDepartment of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
David R Soto-PantojaDepartment of Cancer Biology, Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC, United States.
David A OrnellesDepartment of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Martha A Alexander-MillerDepartment of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Wake Forest University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability of T cells to sense and respond to environmental cues by altering their functional capabilities is critical for a safe and optimally protective immune response. One of the important properties that contributes to this goal is the activation set-point of the T cell. Here we report a new pathway through which TCR transgenic OT-I CD8

Indexed as

AnimalsAutocrine CommunicationCD8-Positive T-LymphocytesInterleukin-4Lymphocyte ActivationMiceMice, Inbred C57BLReceptors, Antigen, T-CellInterleukin-4Receptors, Antigen, T-CellactivationCD8+ T cellfunctional avidityIL-4metabolismNFAT

Identifiers

PMID32300344
PMCPMC7145404
OpenAlexW3014898681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.