GuidelineNature reviews. Molecular cell biology2020
Guidelines and definitions for research on epithelial-mesenchymal transition.
Erratum issuedOpen access · hybridAbstract readGuidelineReview
In one paragraph
Guideline in Nature reviews. Molecular cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1,375 papers.
0numbers the graph read from it
0cells of the map it votes in
1,375citing papers in PubMed
110.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1,375 citing papers in PubMed, 2,241 citations in OpenAlex.
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- NCEH1 promotes breast cancer progression by regulating NRP1 and activating the TNF-α/NF-κB signalling pathway.Cell adhesion & migration · 2026Article
- Metastatic colorectal carcinoma to the thyroid gland: A case report and literature review.Biomedical reports · 2026Article
- Decoding epithelial-mesenchymal transitions with multi-omics.Nature reviews. Genetics · 2026Review
- Anastasis: an unwelcome guest in cancer therapy.Apoptosis : an international journal on programmed cell death · 2026Review
- ALKBH5 in Cancer-Associated Fibroblasts Governs an Epitranscriptomic Axis That Drives Pancreatic Cancer Metastasis.Cancer research · 2026Article
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- Local growth hormone promotes benign prostatic hyperplasia.JCI insight · 2026Article
- Dynamic control of cell state transitions during tissue morphogenesis.The EMBO journal · 2026Review
- SNAI2/SLUG: a key regulator of endothelial-to-mesenchymal transition and vascular remodeling in cardiovascular diseases.Journal of cardiothoracic surgery · 2026Review
- Article
- Alzheimer's disease through the lens of mesenchymal drift: the collapse of cellular identity.BMB reports · 2026Review
- Article
- UNC5B regulates epithelial-to-mesenchymal transition through a SRC-ZEB1 signaling axis to facilitate pancreatic cancer metastasis.Oncogene · 2026Article
1,315 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
48 authors at 20 institutions in 14 countries.
Jing YangDepartments of Pharmacology and Pediatrics, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA. jingyang@ucsd.edu.ORCID http://orcid.org/0000-0001-8410-3549
Parker AntinDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA.
Geert BerxMolecular and Cellular Oncology Lab, Department of Biomedical Molecular Biology, Ghent University, Cancer Research Institute Ghent (CRIG), VIB Center for Inflammation Research, Ghent, Belgium.
Cédric BlanpainLaboratory of Stem Cells and Cancer, Université Libre de Bruxelles, Bruxelles, Belgium.
Thomas BrabletzDepartment of Experimental Medicine 1, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Marianne BronnerDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Kyra CampbellDepartment of Biomedical Science and Bateson Centre, University of Sheffield, Sheffield, UK.
Amparo CanoDepartamento de Bioquímica, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas 'Alberto Sols' (CSIC-UAM), IdiPAZ & Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Jordi CasanovaInstitute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology/Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Barcelona, Spain.
Gerhard ChristoforiDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Shoukat DedharDepartment of Biochemistry and Molecular Biology, University of British Columbia and British Columbia Cancer Research Centre, Vancouver, BC, Canada.
Rik DerynckDepartments of Cell and Tissue Biology, and Anatomy, University of California at San Francisco, San Francisco, CA, USA.
Heide L FordDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Jonas FuxeDepartment of Laboratory Medicine (LABMED), Division of Pathology, Karolinska University Hospital and Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-4576-9377
Antonio García de HerrerosPrograma de Recerca en Càncer, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM) and Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.
Gregory J GoodallCentre for Cancer Biology, An alliance of SA Pathology and University of South Australia, Adelaide, SA, Australia.
Anna-Katerina HadjantonakisDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ruby Y J HuangSchool of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chaya KalcheimDepartment of Medical Neurobiology, Institute for medical Research Israel-Canada and the Safra Center for Neurosciences, Hebrew University of Jerusalem, Hadassah Medical School, Jerusalem, Israel.
Raghu KalluriDepartment of Cancer Biology, Metastasis Research Center, MD Anderson Cancer Center, Houston, TX, USA.
Yibin KangDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-1626-6730
Yeesim Khew-GoodallCentre for Cancer Biology, an Alliance of SA Pathology and the University of South Australia, Adelaide, SA, Australia.
Herbert LevineDepartment of Physics, Northeastern University, Boston, MA, USA.
Jinsong LiuDepartment of Anatomic Pathology, The Division of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Gregory D LongmoreDepartment of Medicine (Oncology) and Department of Cell Biology and Physiology, ICCE Institute, Washington University, St. Louis, MO, USA.
Sendurai A ManiDepartment of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Joan MassaguéCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Roberto MayorDepartment of Cell and Developmental Biology, University College London, London, UK.ORCID http://orcid.org/0000-0001-9053-9613
David McClayDepartment of Biology, Duke University, Durham, NC, USA.
Keith E MostovDepartments of Anatomy and Biochemistry/Biophysics, University of California, San Francisco, School of Medicine, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8123-6247
Donald F NewgreenMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0002-3467-6389
M Angela NietoInstituto de Neurociencias (CSIC-UMH) Avda Ramon y Cajal s/n, Sant Joan d´Alacant, Spain.ORCID http://orcid.org/0000-0002-3538-840X
Alain PuisieuxUniversité Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France.ORCID http://orcid.org/0000-0002-9938-3798
Raymond RunyanDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA.ORCID http://orcid.org/0000-0002-7410-916X
Pierre SavagnerINSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, University Paris-Saclay, Villejuif, France.
Ben StangerDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Marc P StemmlerDepartment of Experimental Medicine 1, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0000-0002-7866-3686
Yoshiko TakahashiDepartment of Zoology, Graduate School of Science, Kyoto University, Kyoto, Japan.
Masatoshi TakeichiRIKEN Center for Biosystems Dynamics Research, Kobe, Japan.ORCID http://orcid.org/0000-0002-9931-3378
Eric TheveneauCentre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France.ORCID http://orcid.org/0000-0001-6510-5717
Jean Paul ThieryGuangzhou Regenerative Medicine and Health, Guangdong Laboratory, Guangzhou, China.ORCID http://orcid.org/0000-0003-0478-5020
Erik W ThompsonSchool of Biomedical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Woolloongabba, QLD, Australia.ORCID http://orcid.org/0000-0002-9723-4924
Robert A WeinbergWhitehead Institute for Biomedical Research, Department of Biology, MIT Ludwig Center for Molecular Oncology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Elizabeth D WilliamsAustralian Prostate Cancer Research Centre-Queensland (APCRC-Q) and Queensland Bladder Cancer Initiative (QBCI), School of Biomedical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD, Australia.ORCID http://orcid.org/0000-0002-3364-6655
Jianhua XingDepartment of Computational and Systems Biology and UPMC-Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-3700-8765
Binhua P ZhouDepartment of Molecular and Cellular Biochemistry and UK Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, USA.
Guojun ShengInternational Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan. sheng@kumamoto-u.ac.jp.
EMT International Association (TEMTIA)
The University of Texas MD Anderson Cancer Center · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEMemorial Sloan Kettering Cancer Center · USSouth Australia Pathology · AUUniversity of Arizona · USUniversity of California, San Francisco · USCalifornia Institute of Technology · USCentre National de la Recherche Scientifique · FRDuke University · USGhent University · BEGuangzhou Regenerative Medicine and Health Guangdong Laboratory · CNHebrew University of Jerusalem · ILInserm · FRInstitute for Research in Biomedicine · ESInstituto de Investigaciones Biomédicas Sols-Morreale · ESInstituto de Neurociencias · ESKarolinska University Hospital · SEKumamoto University · JPKyoto University · JPMolecular Oncology (United States) · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MVIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9MSOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7MTech Development CoreP41HD088362 · NICHD · UNIVERSITY OF ARIZONA · PI ANTIN, PARKER BRUCE · 2017 to 2021
$3.2MThree-dimensional organoid models to study breast cancer progressionR37CA232209 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANT, SHILPA · 2018 to 2024
$3.0MTumor stromal effects of DDR2 in metastasis regulationR01CA223758 · NCI · WASHINGTON UNIVERSITY · PI LONGMORE, GREGORY D. · 2018 to 2022
$1.9MRole of the Snail1-Twist-p21 axis on cell cycle arrest and renal fibrosis developmentR01DK119232 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XING, JIANHUA · 2019 to 2022
$1.4MNCI NIH HHS P30 CA016672NCI NIH HHS P30 CA023100NCI NIH HHS R01 CA223758NCI NIH HHS R37 CA232209NICHD NIH HHS P41 HD088362NIDDK NIH HHS R01 DK119232NIEHS NIH HHS P30 ES006694Wellcome Trust 204615/Z/16/Z
Abstract
Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by 'the EMT International Association' (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT.
Indexed as
Epithelial-Mesenchymal TransitionAnimalsBiomedical ResearchCell MovementCell PlasticityConsensusDevelopmental BiologyHumansNeoplasmsTerminology as Topic
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.