ArticleBMJ open diabetes research & care2020
Diabetes mellitus as a risk factor for compression neuropathy: a longitudinal cohort study from southern Sweden.
Article in BMJ open diabetes research & care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- RETRACTED: Investigating the association between diabetes and carpal tunnel syndrome: A systematic review and meta-analysis approach.PloS one · 2024Pooled it
- The prevalence of ulnar neuropathy at the elbow and ulnar nerve dislocation in recreational wheelchair marathon athletes.PloS one · 2020Trial
- Article
- Metabolic Dysregulation, Inflammation, and Median Nerve Dysfunction in Patients with Type 2 Diabetes Mellitus with Carpal Tunnel Syndrome.International journal of molecular sciences · 2026Article
- Health-related factors and epigenetic alterations in metabolic comorbidities patients and smokers with carpal tunnel syndrome: a preliminary investigation of patient-derived samples.Journal of orthopaedic surgery and research · 2026Article
- Predictors of Peripheral Neuropathy in Metabolic Disease: A Multivariable Analysis Incorporating the Toronto Clinical Scoring System and Sudomotor Assessment.Medicina (Kaunas, Lithuania) · 2026Article
- Review
- Efficacy analysis of quadruple nerve decompression surgery for lower limb diabetic peripheral neuropathy.Frontiers in surgery · 2025Article
- Presurgical management of ulnar nerve entrapment in patients with and without diabetes mellitus.Scientific reports · 2024Article
- Carpal tunnel syndrome.Nature reviews. Disease primers · 2024Review
- Article
- The Unpredictable Ulnar Nerve-Ulnar Nerve Entrapment from Anatomical, Pathophysiological, and Biopsychosocial Aspects.Diagnostics (Basel, Switzerland) · 2024Review
- Serum biomarkers in patients with hand-arm vibration injury and in controls.Scientific reports · 2024Article
- Surgery for carpal tunnel syndrome in patients with and without diabetes-Is there a difference in the frequency of surgical procedures?PloS one · 2024Observational
- Towards a practical use of text mining approaches in electrodiagnostic data.Scientific reports · 2023Article
- Quantification of heat shock proteins in the posterior interosseous nerve among subjects with type 1 and type 2 diabetes compared to healthy controls.Frontiers in neuroscience · 2023Article
- Is Smoking Associated with Carpal Tunnel Syndrome? A Meta-Analysis.Healthcare (Basel, Switzerland) · 2022Review
- Carpal Tunnel Syndrome and Ulnar Nerve Entrapment Are Associated with Impaired Psychological Health in Adults as Appraised by Their Increased Use of Psychotropic Medication.Journal of clinical medicine · 2022Article
- Electrodiagnostic Testing and Nerve Ultrasound of the Carpal Tunnel in Patients with Type 2 Diabetes.Journal of clinical medicine · 2022Article
- Carpal Tunnel Syndrome and Diabetes-A Comprehensive Review.Journal of clinical medicine · 2022Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCompression neuropathies (CN) in the upper extremity, the most common being carpal tunnel syndrome (CTS) and ulnar nerve entrapment (UNE), are frequent among patients with diabetes mellitus (DM). Earlier studies have shown contradicting results regarding DM as a risk factor for CN. Thus, the aim of the present population-based, longitudinal study was to explore potential associations between DM, CTS, and UNE during long-term follow-up. RESEARCH DESIGN AND
methodsA total of 30 466 participants aged 46-73 years, included in the population-based Malmö Diet and Cancer Study during 1991-1996, were followed up in Swedish national registries regarding incident CTS and UNE until 2016. Associations between prevalent DM at baseline and incident CTS or UNE were calculated using Cox proportional hazard models, adjusted for baseline confounders, such as sex, age at study entry, smoking, hypertension, use of antihypertensive treatment, alcohol consumption, and body mass index (BMI). HbA1c and fasting plasma glucose levels had been measured at baseline in a subgroup of 5508 participants and were related to incident CTS and UNE in age and sex-adjusted binary logistic regression models.
resultsA total of 1081 participants developed CTS and 223 participants developed UNE during a median follow-up of 21 years. Participants with incident CTS or UNE had higher prevalence of DM and higher BMI at baseline. Using multivariate Cox regression models, prevalent DM at baseline was independently associated with both incident CTS (HR 2.10; 95% CI 1.65 to 2.70, p<0.0001) and incident UNE (HR 2.20; 95% CI 1.30 to 3.74, p=0.003). Higher levels of HbA1c and plasma glucose were associated with an increased risk for CTS, but not for UNE.
conclusionThis study establishes DM as a major risk factor in the development of both CTS and UNE. Furthermore, a higher BMI is associated with both CTS and UNE. Finally, hyperglycemia seems to affect the median and ulnar nerves differently.
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