Evidence map›Paper›PMID 32299856›Full record

ArticleThe European respiratory journal2020

Novel airway smooth muscle-mast cell interactions and a role for the TRPV4-ATP axis in non-atopic asthma.

Sara J Bonvini, Mark A Birrell, Eric Dubuis, John J Adcock, Michael A Wortley, Pauline Flajolet, Peter Bradding, Maria G Belvisi

Open access · hybridAbstract read
In one paragraph

Article in The European respiratory journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Clinical and Biological Features of a Thickened Basement Membrane Zone in Asthma.American journal of respiratory and critical care medicine · 2025
    Article
  6. Article
  7. Testosterone Enhances KInternational journal of molecular sciences · 2024
    Article
  8. Article
  9. Review
  10. Review
  11. Mechanosensitive channels in lung disease.Frontiers in physiology · 2023
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Endothelial TRPV4 channels in lung edema and injury.Current topics in membranes · 2022
    Review
  18. Inhibition of TRPV4 attenuates ferroptosis against LPS-induced ALI via CaTurkish journal of biology = Turk biyoloji dergisi · 2022
    Article
  19. Current research in food science · 2022
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Sara J BonviniRespiratory Pharmacology Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK.
Mark A BirrellRespiratory Pharmacology Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK.
Eric DubuisRespiratory Pharmacology Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK.
John J AdcockRespiratory Pharmacology Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK.
Michael A WortleyRespiratory Pharmacology Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK.
Pauline FlajoletRespiratory Pharmacology Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK.
Peter BraddingDept of Infection, Immunity and Inflammation, University of Leicester University, Institute for Lung Health, Glenfield Hospital, Leicester, UK.
Maria G BelvisiRespiratory Pharmacology Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK m.belvisi@imperial.ac.uk.
Imperial College London · GBAstraZeneca (Sweden) · SEUniversity of Leicester · GB

Funding

Medical Research Council MR/K020293/1Wellcome Trust 207504/B/17/Z
6 · The paper itself

Abstract

Mast cell-airway smooth muscle (ASM) interactions play a major role in the immunoglobulin (Ig)E- dependent bronchoconstriction seen in asthma but less is known about IgE-independent mechanisms of mast cell activation. Transient receptor potential cation channel, subfamily V, member 4 (TRPV4) activation causes contraction of human ASM

Indexed as

AsthmaTRPV Cation ChannelsAdenosine TriphosphateAnimalsCell CommunicationGuinea PigsMuscle ContractionMuscle, SmoothAdenosine TriphosphateTRPV Cation Channels

Identifiers

PMID32299856
PMCPMC7330131
OpenAlexW3017384987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.