Evidence map›Paper›PMID 32299836›Full record

ArticleJournal of cell science2020

A genetic interaction map centered on cohesin reveals auxiliary factors involved in sister chromatid cohesion in

Su Ming Sun, Amandine Batté, Mireille Elmer, Sophie C van der Horst, Tibor van Welsem, Gordon Bean, Trey Ideker, Fred van Leeuwen, Haico van Attikum

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Prefoldin Function in Cellular Protein Homeostasis and Human Diseases.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Su Ming SunDepartment of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, Netherlands.
Amandine BattéDepartment of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, Netherlands.
Mireille ElmerDepartment of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, Netherlands.
Sophie C van der HorstDepartment of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, Netherlands.
Tibor van WelsemDivision of Gene Regulation, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands.
Gordon BeanBioinformatics and Systems Biology Program, University of California, San Diego; La Jolla, CA, 92093, USA.
Trey IdekerBioinformatics and Systems Biology Program, University of California, San Diego; La Jolla, CA, 92093, USA.ORCID 0000-0002-1708-8454
Fred van LeeuwenDivision of Gene Regulation, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands.ORCID 0000-0002-7267-7251
Haico van AttikumDepartment of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, Netherlands h.van.attikum@lumc.nl.ORCID 0000-0001-8590-0240
Leiden University Medical Center · NLThe Netherlands Cancer Institute · NLNational Foundation for Cancer Research · USUniversity of California San Diego · US

Funding

TR&D 3 - Network Guided Machine LearningP41GM103504 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2012 to 2024
$17.3M
A Systems Approach to Mapping the DNA Damage ResponseR01ES014811 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2005 to 2021
$8.6M
NIEHS NIH HHS R01 ES014811NIGMS NIH HHS P41 GM103504
6 · The paper itself

Abstract

Eukaryotic chromosomes are replicated in interphase and the two newly duplicated sister chromatids are held together by the cohesin complex and several cohesin auxiliary factors. Sister chromatid cohesion is essential for accurate chromosome segregation during mitosis, yet has also been implicated in other processes, including DNA damage repair, transcription and DNA replication. To assess how cohesin and associated factors functionally interconnect and coordinate with other cellular processes, we systematically mapped the genetic interactions of 17 cohesin genes centered on quantitative growth measurements of >52,000 gene pairs in the budding yeast

Indexed as

Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCell Cycle ProteinsChromatidsChromosomal Proteins, Non-HistoneChromosome SegregationCohesinsCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsSaccharomyces cerevisiae ProteinsCohesinCohesinopathyGenetic interaction mappingIrc15PrefoldinSister chromatid cohesion

Identifiers

PMID32299836
PMCPMC7325435
OpenAlexW3016830953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.