ArticleJournal of the American College of Cardiology2020
Transvalvular Flow Rate Determines Prognostic Value of Aortic Valve Area in Aortic Stenosis.
Article in Journal of the American College of Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Management of aortic stenosis: a systematic review of clinical practice guidelines and recommendations.European heart journal. Quality of care & clinical outcomes · 2021Pooled it
- Invasive transvalvular flow rate to predict likely severe aortic valve stenosis with low-gradient and normal ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Sinogram-based flow estimation in computed tomography using a physics-informed neural network: Impact of gantry rotation speed, X-ray fluence and pulsed acquisition on accuracy.Medical physics · 2026Article
- Prognostic relevance of persistently low transvalvular flow rate after transcatheter aortic valve replacement in a Japanese population.Journal of echocardiography · 2026Article
- Assessing Aortic Stenosis Severity in Dynamic Left Ventricular Outflow Obstruction Using Echo Doppler.CASE (Philadelphia, Pa.) · 2026Article
- Evolution of Cardiac Damage Across Clinically Defined Stages of Aortic Stenosis in Patients Undergoing TAVR: A Single-Center Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Continuous-wave Doppler interrogation in valvular heart disease: pearls and pitfalls.European heart journal. Imaging methods and practice · 2026Review
- Article
- Multimodality assessment of aortic valve area in aortic stenosis: a multicenter validation study.The international journal of cardiovascular imaging · 2026Observational
- New Insights Into the Diagnosis and Management of Aortic Stenosis.JACC. Asia · 2026Article
- Understanding the Transvalvular Gradient in Aortic Stenosis: A Multifaceted Perspective.Journal of clinical medicine · 2025Review
- Re-Exploration of Flow Rate in Low-Flow, Low-Gradient Aortic Stenosis.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025Article
- Sex-Associated Disparities in Surgical and Percutaneous Management of Aortic Stenosis With Severe Features: Retrospective Analysis From the National Readmission Database.Journal of the American Heart Association · 2025Article
- Severe Mitral Regurgitation in Paradoxical Low-Flow, Low-Gradient Severe Aortic Stenosis.Circulation. Cardiovascular imaging · 2025Article
- Perioperative management of transcatheter aortic valve implantation in acquired von Willebrand syndrome secondary to monoclonal gammopathy: a case report.European heart journal. Case reports · 2025Article
- Discordance between aortic valve gradient and area: do I trust the significant gradient?European heart journal supplements : journal of the European Society of Cardiology · 2025Article
- Cardiac structural and functional damage induced and/or increasingly aggravated by aortic valve stenosis.Cardiovascular diagnosis and therapy · 2025Article
- Diagnostic Challenges in the Management of Aortic Valve Stenosis and the Role of Imaging: A Narrative Review.Journal of clinical medicine · 2025Review
- Machine learning cluster analysis identifies increased 12-month mortality risk in transcatheter aortic valve replacement recipients.Frontiers in cardiovascular medicine · 2025Article
- Severe mitral stenosis as a cause of paradoxical low-flow, low-gradient severe aortic stenosis: an explorative study on hemodynamics and outcomes.Frontiers in cardiovascular medicine · 2025Article
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundAortic valve area (AVA) ≤1.0 cm
objectivesThis study aimed to evaluate the effect of flow rate on prognostic value of AVA in AS.
methodsIn total, 1,131 patients with moderate or severe AS and complete clinical follow-up were included as part of a longitudinal database. The effect of flow rate (ratio of stroke volume to ejection time) on prognostic value of AVA ≤1.0 cm
resultsFlow rate had a significant effect on prognostic value of AVA. AVA ≤1.0 cm
conclusionsTransvalvular flow rate determines prognostic value of AVA in AS. AVA measured at low flow rate is not a good prognostic marker and therefore not a good diagnostic marker for truly severe AS. Flow rate assessment should be incorporated into clinical diagnosis, classification, and prognosis of AS.
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