Evidence map›Paper›PMID 32299512›Full record

ArticleTrials2020

Mechanisms of change in brief treatments for borderline personality disorder: a protocol of a randomized controlled trial.

Ueli Kramer, Loris Grandjean, Hélène Beuchat, Stéphane Kolly, Philippe Conus, Yves de Roten, Bogdan Draganski, Jean-Nicolas Despland

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03717818 (Mechanisms of Change in Brief Treatment for Borderline Personality Disorder), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03717818 naunknown statusnot on this map

Mechanisms of Change in Brief Treatment for Borderline Personality Disorder: A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of Lausanne HospitalsRan2018 to 2022Enrolled80ConditionsBorderline Personality DisorderArmsGood Psychiatric Management - Brief, treatment as usual
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ueli KramerInstitute of Psychotherapy and General Psychiatry Service, Department of Psychiatry, Lausanne University Clinic and University of Lausanne and Lausanne University Hospital, Place Chauderon 18, CH-1003, Lausanne, Switzerland. Ueli.Kramer@chuv.ch.ORCID http://orcid.org/0000-0002-5603-0394
Loris GrandjeanInstitute of Psychotherapy and General Psychiatry Service, Department of Psychiatry, Lausanne University Clinic and University of Lausanne and Lausanne University Hospital, Place Chauderon 18, CH-1003, Lausanne, Switzerland.
Hélène BeuchatInstitute of Psychotherapy and General Psychiatry Service, Department of Psychiatry, Lausanne University Clinic and University of Lausanne and Lausanne University Hospital, Place Chauderon 18, CH-1003, Lausanne, Switzerland.
Stéphane KollyGeneral Psychiatry Service, Department of Psychiatry, Lausanne University Clinic and University of Lausanne, Lausanne, Switzerland.
Philippe ConusGeneral Psychiatry Service, Department of Psychiatry, Lausanne University Clinic and University of Lausanne, Lausanne, Switzerland.
Yves de RotenInstitute of Psychotherapy and General Psychiatry Service, Department of Psychiatry, Lausanne University Clinic and University of Lausanne and Lausanne University Hospital, Place Chauderon 18, CH-1003, Lausanne, Switzerland.
Bogdan DraganskiDepartment of Clinical Neurosciences, Lausanne University Clinic and University of Lausanne, Lausanne, Switzerland.
Jean-Nicolas DesplandInstitute of Psychotherapy and General Psychiatry Service, Department of Psychiatry, Lausanne University Clinic and University of Lausanne and Lausanne University Hospital, Place Chauderon 18, CH-1003, Lausanne, Switzerland.
University of Lausanne · CHUniversity Hospital of Lausanne · CH

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 100014_179457/1
6 · The paper itself

Abstract

backgroundBorderline personality disorder (BPD) is one of the most frequent, most debilitating and lethal mental conditions and is associated with a serious burden of disease. Treatment for patients with BPD involves structured psychotherapy, and may involve brief psychiatric treatment as first-line intervention. No controlled study has assessed the effectiveness of such brief intervention. Whereas most psychotherapy studies in patients with BPD focus on the effectiveness of the intervention, we still lack an understanding of how and why these effects are produced from a patient process perspective. It is therefore of utmost importance to study the treatment-underlying mechanisms of change. The present study plans to apply novel measurement methods for assessing change in two central psychobiological processes in BPD: emotion and socio-cognitive processing. The study uses theory-driven and ecologically valid experimental tasks, which take the patient's individual experience as the anchor, by integrating methodology from psychotherapy process and neurofunctional imagery research.

methodsThe aim of this two-arm, randomized controlled study is to test the effects (i.e., symptom reduction) and the underlying mechanisms of change associated with a brief psychiatric treatment (10 sessions over 4 months), compared with treatment as usual. Participants (N = 80 patients with BPD) undergo assessments at four points (intake, 2 months, discharge, and 12-month follow up). In addition to symptom measures, individuals undergo a 2-step assessment for the potential mechanisms of change (i.e., emotion and socio-cognitive processing): (1) behavioral and (2) (for a sub-sample) neurofunctional. We hypothesize that change in the mechanisms explains the treatment effects. DISCUSSION: This study uses an easy-to-implement treatment of BPD, and a sophisticated assessment procedure to demonstrate the critical role of psychobiological change in emotion and socio-cognitive processing in brief treatments. It will help increase the effectiveness of brief treatment for BPD and help diminish the societal burden of disease related to BPD, in these early stages of treatment. TRIAL REGISTRATION {2}: ClinicalTrials.gov: NCT03717818. Registered on 24 October 2018). Protocol version {3} number 2 from 9 February 2018.

Indexed as

CognitionEmotionsAdolescentAdultBorderline Personality DisorderChildChild, PreschoolCrisis InterventionFemaleFollow-Up StudiesFunctional LateralityHumansInfantInfant, NewbornInformed ConsentMaleBorderline personality disorderEmotional processingfMRIMechanisms of changeProcessPsychiatric treatmentRandomized controlled trialTheory of mind processing

Identifiers

PMID32299512
PMCPMC7160891
OpenAlexW3016620754

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.