Evidence map›Paper›PMID 32299446›Full record

ArticleJournal of translational medicine2020

The Great Debate at "Melanoma Bridge", Naples, December 7th, 2019.

Paolo A Ascierto, Sanjiv S Agarwala, Alexander Eggermont, Jeffrey E Gershenwald, Jean-Jacques Grob, Omid Hamid, Olivier Michielin, Michael Postow, Igor Puzanov, Hassane M Zarour and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 5 countries.

Paolo A AsciertoUnit of Melanoma, Cancer Immunotherapy and Innovative Therapy, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Via Mariano Semmola, 80131, Naples, Italy. paolo.ascierto@gmail.com.
Sanjiv S AgarwalaTemple University School of Medicine, Philadelphia, PA, USA.
Alexander EggermontPrincess Máxima Center Research Directorate, CS, 3584 CS, Utrecht, The Netherlands.
Jeffrey E GershenwaldDepartment of Surgical Oncology and Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jean-Jacques GrobHopital de la Timone, Aix-Marseille University, Marseille, France.
Omid HamidAngeles Clinic & Research Institute, Santa Monica, CA, USA.
Olivier MichielinOncology Service, Precision Oncology Center, Oncology Department, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Michael PostowMemorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA.
Igor PuzanovRoswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Hassane M ZarourHillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Corrado CaracòDepartment Melanoma, Soft Tissue, Muscle-Skeletal and Head-Neck, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Naples, Italy.
Alessandro TestoriDermatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITAngeles Clinic and Research Institute · USHôpital de la Timone · FRIstituti di Ricovero e Cura a Carattere Scientifico · ITMemorial Sloan Kettering Cancer Center · USPrincess Máxima Center · NLRoswell Park Comprehensive Cancer Center · USTemple University · USThe University of Texas MD Anderson Cancer Center · USUniversity Hospital of Lausanne · CHUPMC Hillman Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

The Great Debate session at the 2019 Melanoma Bridge congress (December 5-7, Naples, Italy) featured counterpoint views from experts on five topical issues in melanoma. These were whether to choose local intratumoral treatment or systemic treatment, whether patients with stage IIIA melanoma require adjuvant therapy or not, whether treatment is better changed at disease progression or during stable disease, whether adoptive cell transfer (ACT) therapy is more appropriate used before or in combination with checkpoint inhibition therapy, and whether treatment can be stopped while the patient is still on response. As was the case for previous meetings, the debates were assigned by meeting Chairs. As such, positions taken by each of the melanoma experts during the debates may not have reflected their respective personal approach.

Indexed as

MelanomaSkin NeoplasmsCombined Modality TherapyHumansImmunotherapyItalyAdjuvantAnti-CTLA-4Anti-PD-1BRAF inhibitorMEK inhibitorMelanomaNeoadjuvantStaging immunotherapyTargeted therapy

Identifiers

PMID32299446
PMCPMC7164218
OpenAlexW3017177224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.