Evidence map›Paper›PMID 32299429›Full record

ArticleBMC ophthalmology2020

Autoimmune retinopathy associated with monoclonal gammopathy of undetermined significance: a case report.

Emily A Eton, Gary Abrams, Naheed W Khan, Abigail T Fahim

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Ocular complications of plasma cell dyscrasias.European journal of ophthalmology · 2023
    Review
  4. Article
  5. Review
  6. Rituximab for non-infectious Uveitis and Scleritis.Journal of ophthalmic inflammation and infection · 2021
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Emily A EtonKellogg Eye Center, University of Michigan, 1000 Wall Street, Ann Arbor, MI, 48105, USA. etone@med.umich.edu.
Gary AbramsKresge Eye Institute, Wayne State University, 4717 St. Antoine, Detroit, MI, 48201, USA.
Naheed W KhanKellogg Eye Center, University of Michigan, 1000 Wall Street, Ann Arbor, MI, 48105, USA.
Abigail T FahimKellogg Eye Center, University of Michigan, 1000 Wall Street, Ann Arbor, MI, 48105, USA.
University of Michigan–Ann Arbor · USKresge Eye Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMonoclonal gammopathy of undetermined significance (MGUS) is a plasma cell dyscrasia and precursor to multiple myeloma. It has known ocular manifestations, but has not previously been shown to have an association with autoimmune retinopathy. CASE PRESENTATION: A 57 year-old female presented with 1 year of progressive, bilateral, peripheral vision loss, photopsias, and nyctalopia. Her fundus examination and extensive ancillary testing were concerning for hereditary versus autoimmune retinopathy. The patient was found to have anti-retinal antibodies against carbonic anhydrase II and enolase proteins with a negative genetic retinal dystrophy panel. Malignancy work-up was negative, but the patient was diagnosed with MGUS, a premalignant condition. The patient was treated with immunosuppressive therapies, with rituximab demonstrating the most robust therapeutic response with respect to patient symptoms and ophthalmic testing.

conclusionsMGUS should be considered as a potential etiology of autoimmune retinopathy in patients without other autoimmune or malignant disease processes. Immunosuppressive therapy may be helpful in limiting disease progression, with rituximab showing efficacy in retinopathy refractory to other agents.

Indexed as

AutoimmunityAutoimmune DiseasesDark AdaptationDisease ProgressionElectroretinographyFemaleFluorescein AngiographyFundus OculiHumansMiddle AgedParaproteinemiasRetinaRetinal DiseasesTomography, Optical CoherenceVisual FieldsAutoimmune retinopathyMonoclonal gammopathy of undetermined significancePlasma cell dyscrasias

Identifiers

PMID32299429
PMCPMC7160953
OpenAlexW3016543529

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.