Evidence map›Paper›PMID 32299357›Full record

ArticleBMC immunology2020

Thalidomide with blockade of co-stimulatory molecules prolongs the survival of alloantigen-primed mice with cardiac allografts.

Maoshu Zhu, Yunhan Ma, Kai Tan, Liyi Zhang, Zhaowei Wang, Yongsheng Li, Yingyu Chen, Junjun Guo, Guoliang Yan, Zhongquan Qi

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Maoshu Zhu *Xiang'an Branch, The First Affiliated Hospital of Xiamen University, Xiamen, 361100, Fujian, China.
Yunhan Ma *Organ Transplantation institute, School of Medicine, Xiamen University, Xiamen, 361100, Fujian, China.
Kai TanGrade 2015 Clinical Medicine, Fuzhou Medical College of Nanchang University, Fuzhou, 344000, Jiangxi, China.
Liyi ZhangOrgan Transplantation institute, School of Medicine, Xiamen University, Xiamen, 361100, Fujian, China.
Zhaowei WangXiang'an Branch, The First Affiliated Hospital of Xiamen University, Xiamen, 361100, Fujian, China.
Yongsheng LiXiang'an Branch, The First Affiliated Hospital of Xiamen University, Xiamen, 361100, Fujian, China.
Yingyu ChenOrgan Transplantation institute, School of Medicine, Xiamen University, Xiamen, 361100, Fujian, China.
Junjun GuoOrgan Transplantation institute, School of Medicine, Xiamen University, Xiamen, 361100, Fujian, China.
Guoliang YanOrgan Transplantation institute, School of Medicine, Xiamen University, Xiamen, 361100, Fujian, China. zhuanyiyan@126.com.
Zhongquan QiOrgan Transplantation institute, School of Medicine, Xiamen University, Xiamen, 361100, Fujian, China. zqqi@xmu.edu.cn.
Xiamen University · CNFifth Hospital of Shijiazhuang · CNFirst Affiliated Hospital of Xiamen University · CNNanchang University · CN

Funding

Fujian Provincial Health Education Joint Research Project WKJ2016-2-20National Key R&D Program of China 2018YFA0108304National Natural Science Foundation of China 81771271Natural Science Foundation of Fujian Province (CN) 2018D0022
6 · The paper itself

Abstract

backgroundMiscellaneous memory cell populations that exist before organ transplantation are crucial barriers to transplantation. In the present study, we used a skin-primed heart transplantation model in mouse to evaluate the abilities of Thalidomide (TD), alone or in combination with co-stimulatory blockade, using monoclonal antibodies (mAbs) against memory T cells and alloantibodies to prolong the second cardiac survival.

resultsIn the skin-primed heart transplantation model, TD combined with mAbs significantly prolonged the second cardiac survival, accompanied by inhibition of memory CD8

conclusionsOur study indicated a potential synergistic action of TD in combination with with mAbs to suppress the function of memory T cells and increase the survival of second allografts in alloantigen-primed mice.

Indexed as

AllograftsAnimalsAntibodies, MonoclonalCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleForkhead Transcription FactorsGraft RejectionGraft SurvivalHeartHeart TransplantationImmunologic MemoryIsoantigensMiceMice, Inbred BALB CMice, Inbred C57BLAntibodies, MonoclonalForkhead Transcription FactorsIsoantigensThalidomideAlloantigenCardiac allograftCo-stimulatory moleculeMemory T cellMonoclonal antibodyThalidomide

Identifiers

PMID32299357
PMCPMC7164359
OpenAlexW3016772364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.