Evidence map›Paper›PMID 32299258›Full record

ArticleImmunological investigations2020

Exosomes Represent an Immune Suppressive T Cell Checkpoint in Human Chronic Inflammatory Microenvironments.

Gautam N Shenoy, Maulasri Bhatta, Jenni L Loyall, Raymond J Kelleher, Joel M Bernstein, Richard B Bankert

Open access · greenAbstract read
In one paragraph

Article in Immunological investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. The Role of Exosomes in the Pathophysiology of Chronic Rhinosinusitis.Frontiers in cellular and infection microbiology · 2021
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gautam N ShenoyDepartment of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo , Buffalo, New York, USA.ORCID https://orcid.org/0000-0001-6906-8589
Maulasri BhattaImmune Modulatory Therapies LLC , Eden, New York, USA.ORCID https://orcid.org/0000-0001-8824-8884
Jenni L LoyallDepartment of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo , Buffalo, New York, USA.
Raymond J KelleherDepartment of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo , Buffalo, New York, USA.
Joel M BernsteinDepartment of Otolaryngology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo , Buffalo, New York, USA.
Richard B BankertDepartment of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo , Buffalo, New York, USA.
University at Buffalo, State University of New York · USImmune Modulatory Therapies (United States) · US

Funding

Re-activating Memory T Cells in the Microenvironment of Human TumorsR01CA131407 · NCI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BANKERT, RICHARD B · 2008 to 2017
$3.4M
CD4+ Memory T-Cells in Human Tumor MicroenvironmentR01CA108970 · NCI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BANKERT, RICHARD B · 2005 to 2014
$3.0M
Novel Drug for Cancer Immunotherapy that Targets PhosphatidylserineR43CA257721 · NCI · IMMUNE MODULATORY THERAPIES, LLC · PI BANKERT, RICHARD B · 2021 to 2021
$293k
Reversing/Blocking T cell suppression by extracellular vesicles as cancer therapyR43CA224602 · NCI · IMMUNE MODULATORY THERAPIES, LLC · PI BHATTA, MAULASRI · 2018 to 2018
$281k
NCI NIH HHS R01 CA108970NCI NIH HHS R01 CA131407NCI NIH HHS R43 CA224602NCI NIH HHS R43 CA257721
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ImmunomodulationArthritisBiomarkersCellular MicroenvironmentChronic DiseaseDisease SusceptibilityExosomesExtracellular VesiclesHumansImmunohistochemistryImmunophenotypingInflammationLipid MetabolismLymphocyte ActivationNasal PolypsNF-kappa BBiomarkersNF-kappa Bchronic inflammationExosomesganglioside GD3immune checkpointnasal polypsrheumatoid arthritissynovial fluidT cells

Identifiers

PMID32299258
PMCPMC7554261
OpenAlexW3016911123

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.