ArticleKorean journal of anesthesiology2020
Influence of alcohol consumption on blood coagulation in rotational thromboelastometry (ROTEM): an in-vivo study.
Article in Korean journal of anesthesiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Alcohol use disorder increases risk of major adverse limb events following lower-extremity revascularization for chronic limb-threatening ischemia.Journal of vascular surgery · 2026Article
- Evaluation of alcohol intoxication on primary and secondary haemostasis - results from comprehensive coagulation testing.International journal of legal medicine · 2025Article
- Bleeding risk and thrombosis in cirrhosis: a paradox with a need to address them.Hepatobiliary surgery and nutrition · 2023Article
- Effect of acute alcohol intoxication on mortality, coagulation, and fibrinolysis in trauma patients.PloS one · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
backgroundTwenty-five to 85% of trauma patients are under the influence of alcohol in addition to experiencing injury-related coagulation impairment. Viscoelastic point-of-care tests (thrombelastography [TEG], rotational thromboelastometry [ROTEM]) are popular tools for rapid hemostasis assessment and therapeutic decision-making in this and other settings. While alcohol affects these tests in-vitro, their specific effects in-vivo are unclear. Therefore, we evaluated the effects of alcohol ingestion on ROTEM parameters.
methodsTwenty volunteers provided informed consent to drinking red wine, whisk(e)y, or vodka to a target blood alcohol concentration of 1 ‰ within one hour, calculated with the Widmark formula. Blood samples were collected before drinking, at a breath alcohol concentration of 0.5 ‰, and at 1.0 ‰, but no later than one hour. After each blood collection, ExTEM and FibTEM tests were performed directly "at the bedside."
resultsAll participants had a blood alcohol concentration (BAC) of 0.00 ‰ at the beginning. The mean BACs at the second and third collection were 0.48 and 0.76 ‰, respectively. There were no significant differences in the ExTEM parameters. FibTEM measurements showed a significant difference at the A10 value (13.0 vs. 14.0 mm, P = 0.014) and a trend at the maximum amplitude (maximum clot firmness [MCF] 13.7 vs. 16.2 mm, P = 0.075). We saw no significant differences in fibrinolysis parameters and no hyperfibrinolysis in our ROTEM measurements.
conclusionsEthanol ingestion can impair early fibrin polymerization. These results might be of special relevance in trauma and support routine application of ROTEM/TEG in such cases.
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