Evidence map›Paper›PMID 32299107›Full record

ArticleAmerican journal of perinatology2021

Unintended Consequences Following the 2014 American Academy of Pediatrics Policy Change for Palivizumab Prophylaxis among Infants Born at Less than 29 Weeks' Gestation.

Mitchell Goldstein, Leonard R Krilov, Jaime Fergie, Lance Brannman, Sally W Wade, Amanda M Kong, Christopher S Ambrose

Abstract read
In one paragraph

Article in American journal of perinatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mitchell GoldsteinDivision of Neonatology, Department of Pediatrics, Loma Linda University Children's Hospital, Loma Linda, California.
Leonard R KrilovDivision of Pediatric Infectious Disease, Children's Medical Center, NYU Winthrop, Mineola, New York.
Jaime FergieDepartment of Infectious Diseases, Driscoll Children's Hospital, Corpus Christi, Texas.
Lance BrannmanBiopharmaceutical Medical Department, AstraZeneca, Gaithersburg, Maryland.
Sally W WadeWade Outcomes Research and Consulting, Salt Lake City, Utah.
Amanda M KongLife Sciences Department, IBM Watson Health, Cambridge, Massachusetts.
Christopher S AmbroseBiopharmaceutical Medical Department, AstraZeneca, Gaithersburg, Maryland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study is to compare outpatient respiratory syncytial virus (RSV) immunoprophylaxis (IP) use and relative RSV hospitalization (RSVH) rates for infants <29 weeks' gestational age (wGA) versus term infants before and after the 2014 American Academy of Pediatrics (AAP) policy change. STUDY

designInfants were identified in the MarketScan Commercial and Multi-State Medicaid databases. Outpatient RSV IP receipt and relative <29 wGA/term hospitalization risks in 2012 to 2014 and 2014 to 2016 were assessed using rate ratios and a difference-in-difference model.

resultsOutpatient RSV IP receipt by infants <29 wGA and aged <3 months in the Commercial and Medicaid populations and those aged 3 to <6 months in the Medicaid population declined after 2014. Relative RSVH risks for infants <29 wGA were numerically greater after 2014, with infants aged <3 months and Medicaid infants experiencing the greatest increases. Difference-in-difference results indicated a significantly increased relative risk of RSVH for infants <29 wGA versus term (both cohorts aged 0 to <6 months) in the Medicaid-insured population (1.68,

conclusionThe 2014 policy change was associated with a decrease in RSV IP use and an increase in RSVH risk among otherwise healthy infants <29 wGA.

Indexed as

PediatricsPre-Exposure ProphylaxisRespiratory Syncytial Virus InfectionsAntiviral AgentsDatabases, FactualGestational AgeHospitalizationHumansInfantInfant, NewbornInfant, PrematureMedicaidPalivizumabPolicyUnited StatesAntiviral AgentsPalivizumab

Identifiers

PMID32299107
PMCPMC8397527

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.