Evidence map›Paper›PMID 32299088›Full record

ArticlePediatric research2021

Gene expression profile in cases of infectious death in infancy.

Linda Ferrante, Siri H Opdal, Ståle Nygård, Åshild Vege, Torleiv O Rognum

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Article in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Linda FerranteDepartment of Forensic Sciences, Section of Forensic Pathology and Clinical Forensic Medicine, Oslo of University Hospital, Oslo, Norway. liferr@ous-hf.no.
Siri H OpdalDepartment of Forensic Sciences, Section of Forensic Pathology and Clinical Forensic Medicine, Oslo of University Hospital, Oslo, Norway.
Ståle NygårdBioinformatics Core Facility, Institute for Medical Informatics, Oslo University Hospital, Oslo, Norway.
Åshild VegeDepartment of Forensic Sciences, Section of Forensic Pathology and Clinical Forensic Medicine, Oslo of University Hospital, Oslo, Norway.
Torleiv O RognumDepartment of Forensic Sciences, Section of Forensic Pathology and Clinical Forensic Medicine, Oslo of University Hospital, Oslo, Norway.
Oslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetic predispositions in cases suffering sudden unexpected infant death have been a research focus worldwide during the past decade. Despite large efforts, there is still uncertainty concerning the molecular pathogenesis of these deaths. With genetic technology in constant development, the possibility of an alternative approach into this research field has become available, like mRNA expression studies.

methodsIn this study, we investigated mRNA gene expression in 14 cases who died suddenly and unexpectedly from infection without a history of severe illness prior to death. The control group included eight accidents, two cases of natural death, one undetermined, one case of medical malpractice, and two homicides. The study included tissue from liver, heart, and brain using Illumina whole-genome gene expression assay.

resultsFrom the array, 19 genes showed altered expression in the infectious deaths compared to controls. Tissue from the heart showed 15 genes with altered mRNA expression compared to the control group.

conclusionsDownregulation of KCNE5 in heart tissue from cases of infectious death was of particular interest. Variants of KCNE5 are associated with Brugada syndrome and sudden death and could be responsible for the fatal outcome in the group of infectious death. IMPACT: KCNE5 is downregulated in tissue from the heart in cases of infectious death in infancy. This study provides knowledge about the gene expression profile in cases of infectious death. Variants of a gene known to give increased risk of cardiac arrhythmia is downregulated in cases of infectious death in infancy. The results could give us better knowledge as to why some infants do not survive an infection. This study provides a candidate gene for future studies.

Indexed as

TranscriptomeBacterial InfectionsCase-Control StudiesCause of DeathDeath, SuddenDiagnosis, DifferentialDown-RegulationFemaleGene Expression RegulationGenetic Predisposition to DiseaseHumansInfantLiverMaleMyocardiumPotassium Channels, Voltage-GatedKCNE5 protein, humanPotassium Channels, Voltage-GatedRNA, Messenger

Identifiers

PMID32299088
OpenAlexW3016611341

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.