ArticleDrug and alcohol dependence2020
Pharmacodynamic dose effects of oral cannabis ingestion in healthy adults who infrequently use cannabis.
Article in Drug and alcohol dependence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed.
- Acute Effects of Oral Cannabinoids on Sleep and High-Density EEG in Insomnia: A Pilot Randomised Controlled Trial.Journal of sleep research · 2026Trial
- Evaluating possible 'next day' impairment in insomnia patients administered an oral medicinal cannabis product by night: a pilot randomized controlled trial.Psychopharmacology · 2024Trial
- Preliminary study of the interactive effects of THC and ethanol on self-reported ability and simulated driving, subjective effects, and cardiovascular responses.Psychopharmacology · 2023Trial
- Effects of cannabidiol on simulated driving and cognitive performance: A dose-ranging randomised controlled trial.Journal of psychopharmacology (Oxford, England) · 2022Trial
- Urinary Excretion Profile of Cannabinoid Analytes Following Acute Administration of Oral and Vaporized Cannabis in Infrequent Cannabis Users.Journal of analytical toxicology · 2022Trial
- Identification of ∆9-tetrahydrocannabinol (THC) impairment using functional brain imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Trial
- Gimmie the Gummies: Initial validation of the Edibles Marijuana Purchase Task.Experimental and clinical psychopharmacology · 2026Article
- Modes of Cannabis Use and Mental Health Outcomes Among Older Adults in the United States.Journal of the American Geriatrics Society · 2026Article
- Pilot study comparing the effects of high dose THC to high dose psilocybin and placebo in the set and setting of a classic psychedelic therapy session.Psychopharmacology · 2026Article
- Investigating sex differences in the acute effects of smoked cannabis: a potency-ranging, controlled administration, human laboratory experiment.Psychopharmacology · 2026Article
- An Exploration of Heart Rate Response and Blood Tetrahydrocannabinol (THC) Levels to Commercially Available Cannabis Edibles by Dose.Research square · 2026Article
- Cannabis modalities matter for momentary subjective drug effects.Addictive behaviors · 2026Article
- Behavioral and Self-Report Cognitive Impairment Differences between Fast-Acting, Standard, and Placebo Cannabis Edibles.Research square · 2026Article
- The effects of orally ingested Delta-9-Tetrahydrocannabinol on drivers' hazard perception and risk-taking behaviours: A within-subjects study of medicinal cannabis users.Psychopharmacology · 2026Article
- Effects of naturalistic doses of cannabis edibles on cognition and association with blood THC.Psychopharmacology · 2026Observational
- Edible cannabis use on simulated driving performance.Traffic injury prevention · 2026Article
- Sex differences in the acute effects of cannabis: the need for hypothesis-driven research.Journal of psychiatry & neuroscience : JPN · 2026Article
- Acute and chronic effects of medicinal cannabis use on anxiety and depression in a prospective cohort of patients new to cannabis.Journal of affective disorders · 2025Observational
- Evidence on the effect of in-utero cannabis exposure in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Parasympathetic decreases immediately following self-reported cannabis smoking among adults living with cannabis use disorder.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundPrior controlled cannabis research has mostly focused on smoked cannabis and predominantly included frequent cannabis users. Oral cannabis products ("edibles") make up a large and growing segment of the retail cannabis market. This study sought to characterize the pharmacodynamic effects of oral cannabis among infrequent cannabis users.
methodsSeventeen healthy adults who had not used cannabis for at least 60 days completed four experimental sessions in which they consumed a cannabis-infused brownie that contained 0, 10, 25, or 50 mg THC. Subjective effects, vital signs, cognitive/psychomotor performance, and blood THC concentrations were assessed before and for 8 h after dosing.
resultsRelative to placebo, the 10 mg THC dose produced discriminable subjective drug effects and elevated heart rate but did not alter cognitive/psychomotor performance. The 25 and 50 mg THC doses elicited pronounced subjective effects and markedly impaired cognitive and psychomotor functioning compared with placebo. For all active doses, pharmacodynamic effects did not manifest until 30-60 min after ingestion, and peak effects occurred 1.5-3 h post-administration. Blood THC levels were significantly correlated with some pharmacodynamic drug effects, but were substantially lower than what is typically observed after cannabis inhalation.
conclusionIngestion of oral cannabis dose-dependently altered subjective drug effects and impaired cognitive performance. Unlike inhaled forms of cannabis for which acute effects occur almost immediately, effects of oral cannabis were considerably delayed. In an era of legalization, education about the time course of drug effects for cannabis edibles is needed to facilitate dose titration and reduce acute overdose incidents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.