Evidence map›Paper›PMID 32298676›Full record

ArticleThe Journal of infection2020

Saliva is a reliable tool to detect SARS-CoV-2.

Lorenzo Azzi, Giulio Carcano, Francesco Gianfagna, Paolo Grossi, Daniela Dalla Gasperina, Angelo Genoni, Mauro Fasano, Fausto Sessa, Lucia Tettamanti, Francesco Carinci and 4 more

2 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infection, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 374 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
374citing papers in PubMed, 8 pooled it
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04581889 completednot on this map

Prospective, Seroepidemiological, Non-invasive Cohort Study in Tübingen Children Age-stratified by Nursery and School Attendance

TypeobservationalSponsorUniversity Hospital TuebingenRan2020 to 2022Enrolled2,380ConditionsSevere Acute Respiratory SyndromeArmsDiagnostic test
NCT04604145 nacompletednot on this mapstarted 2021, after this paper: background citation

Evaluation of Self-Collected Saliva Samples Without Viral Transport Media for SARS-CoV-2 Testing Via RT-PCR

TypeinterventionalSponsorDavid Grant U.S. Air Force Medical CenterRan2021 to 2021Enrolled60ConditionsSARS-CoV Infection, Polymerase Chain Reaction, Laboratory TestingArmsSARS-CoV-2 testing on the Eppendorf Thermal Cycler PCR system using self-collected saliva as the specimen
3 · Its place in the literature

Who cites it

374 citing papers in PubMed, 8 syntheses or guidelines pooled it, 706 citations in OpenAlex.

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  7. Saliva sample for the massive screening of SARS-CoV-2 infection: a systematic review.Oral surgery, oral medicine, oral pathology and oral radiology · 2021
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314 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Lorenzo AzziUnit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy. Electronic address: l.azzi@uninsubria.it.
Giulio CarcanoUnit of General, Emergency and Transplant Surgery, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Francesco GianfagnaResearch Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy; Mediterranea Cardiocentro, Naples, Italy.
Paolo GrossiUnit of Infectious and Tropical Diseases, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Daniela Dalla GasperinaUnit of Infectious and Tropical Diseases, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Angelo GenoniLaboratory of Clinical Microbiology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Mauro FasanoLaboratory of Biochemistry and Functional Proteomics, Department of Science and High Technology, University of Insubria, Busto Arsizio (VA), Italy.
Fausto SessaUnit of Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Lucia TettamantiUnit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Francesco CarinciDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Vittorio MaurinoUnit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Agostino RossiLaboratory of Clinical Microbiology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Angelo TagliabueUnit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Andreina BajLaboratory of Clinical Microbiology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
University of Insubria · ITUniversity of Ferrara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study analyzed salivary samples of COVID-19 patients and compared the results with their clinical and laboratory data.

methodsSalivary samples of 25 COVID-19 patients were analyzed by rRT-PCR. The following data were collected: age, sex, comorbidities, drugs. Lactate dehydrogenase (LDH) and ultrasensitive reactive C protein (usRCP) values were registered on the same day when a salivary swab was collected. Prevalence of positivity in saliva and association between clinical data and the cycle threshold as a semiquantitative indicator of viral load were considered.

resultsTwenty-five subjects were recruited into this study, 17 males and 8 females. The mean age was 61.5 +/- 11.2 years. Cardiovascular and/or dysmetabolic disorders were observed in 65.22% of cases. All the samples tested positive for the presence of SARS-CoV-2, while there was an inverse association between LDH and Ct values. Two patients showed positive salivary results on the same days when their pharyngeal or respiratory swabs showed conversion.

conclusionsSaliva is a reliable tool to detect SARS-CoV-2. The role of saliva in COVID-19 diagnosis could not be limited to a qualitative detection of the virus, but it may also provide information about the clinical evolution of the disease.

Indexed as

AgedAged, 80 and overBetacoronavirusCoronavirus InfectionsCOVID-19FemaleHumansMaleMiddle AgedPandemicsPneumonia, ViralReal-Time Polymerase Chain ReactionSalivaSARS-CoV-2CoronavirusCOVID-19nCoV-2019SalivaSARS-CoV-2

Identifiers

PMID32298676
PMCPMC7194805
OpenAlexW3016437870

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.