SynthesisPaediatric anaesthesia2020
Perioperative apnea in infants with hypertrophic pyloric stenosis: A systematic review.
Synthesis in Paediatric anaesthesia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Perioperative apnea in infants with hypertrophic pyloric stenosis: A systematic review.Paediatric anaesthesia · 2020Pooled it
- Machine learning-based prediction of surgical timing and discharge in infantile hypertrophic pyloric stenosis a multimodal predictive approach.Pediatric surgery international · 2026Article
- Carbon Dioxide and Hemoglobin at Presentation with Hypertrophic Pyloric Stenosis-Are They Relevant? Cohort Study and Current Opinions.Children (Basel, Switzerland) · 2025Article
- Utility of Pyloric Length Measurement for Detecting Severe Metabolic Alkalosis in Infants with Hypertrophic Pyloric Stenosis.Pediatric gastroenterology, hepatology & nutrition · 2024Article
- Postoperative apnea after pyloromyotomy for infantile hypertrophic pyloric stenosis.World journal of pediatric surgery · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfantile hypertrophic pyloric stenosis (IHPS) leads to excessive vomiting and metabolic alkalosis, which may subsequently cause apnea. Although it is generally assumed that metabolic derangements should be corrected prior to surgery to prevent apnea, the exact incidence of perioperative apneas in infants with IHPS and the association with metabolic alkalosis are unknown. We performed this systematic review to assess the incidence of apnea in infants with IHPS and to verify the possible association between apnea and metabolic alkalosis.
methodsWe searched MEDLINE, Embase, and Cochrane library to identify studies regarding infants with metabolic alkalosis, respiratory problems, and hypertrophic pyloric stenosis. We conducted a descriptive synthesis of the findings of the included studies.
resultsThirteen studies were included for analysis. Six studies described preoperative apnea, three studies described postoperative apnea, and four studies described both. All studies were of low quality or had other research questions. We found an incidence of 27% of preoperative and 0.2%-16% of postoperative apnea, respectively. None of the studies examined the association between apnea and metabolic alkalosis in infants with IHPS.
conclusionsInfants with IHPS may have a risk to develop perioperative apnea. However, the incidence rates should be interpreted with caution because of the low quality and quantity of the studies. Therefore, further studies are required to determine the incidence of perioperative apnea in infants with IHPS. The precise underlying mechanism of apnea in these infants is still unknown, and the role of metabolic alkalosis should be further evaluated.
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