ArticleToxicological sciences : an official journal of the Society of Toxicology2020
Diesel Exhaust Extract Exposure Induces Neuronal Toxicity by Disrupting Autophagy.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Identification of pesticides associated with an increased risk of Parkinson's disease using a multi-screen approach.Environment international · 2026Article
- Organoid for Air Pollution Toxicity Assessment: Advances and Environmental Applicability.Environment & health (Washington, D.C.) · 2025Review
- Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders.Nutrients · 2025Review
- Interaction Between Traffic-Related Air Pollution and Parkinson Disease Polygenic Risk Score.JAMA network open · 2025Article
- Investigating the neuroprotective effects of strawberry extract against diesel soot-induced motor dysfunction in Drosophila: an in-vivo and in-silico study.In silico pharmacology · 2025Article
- Associations between toxicity-weighted concentrations and dementia risk: Results from the Cardiovascular Health Cognition Study.The Science of the total environment · 2024Article
- Traffic-related air pollution and Parkinson's disease in central California.Environmental research · 2024Article
- Integrating 4-D light-sheet fluorescence microscopy and genetic zebrafish system to investigate ambient pollutants-mediated toxicity.The Science of the total environment · 2023Review
- Neurotoxicity of diesel exhaust extracts in zebrafish and its implications for neurodegenerative disease.Scientific reports · 2022Article
- Micro- and Nanoplastics' Effects on Protein Folding and Amyloidosis.International journal of molecular sciences · 2022Review
- Air Pollution and the Risk of Parkinson's Disease: A Review.Movement disorders : official journal of the Movement Disorder Society · 2022Review
- Exposure to environmentally relevant concentrations of ambient fine particulate matter (PMParticle and fibre toxicology · 2022Article
- Preventing Parkinson's Disease: An Environmental Agenda.Journal of Parkinson's disease · 2022Review
- The utility of alternative models in particulate matter air pollution toxicology.Current research in toxicology · 2022Article
- MicroRNA expression changes in Parkinson's disease (PD) patients' leukocytes prior to and following deep brain stimulation (DBS).American journal of neurodegenerative disease · 2021Article
- Studying the Pathophysiology of Parkinson's Disease Using Zebrafish.Biomedicines · 2020Review
- A bibliometric and systematic review of the global impact of air pollution on Alzheimer's disease: Insights from cohort studies.Journal of Alzheimer's disease reportsReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The vast majority of neurodegenerative disease cannot be attributed to genetic causes alone and as a result, there is significant interest in identifying environmental modifiers of disease risk. Epidemiological studies have supported an association between long-term exposure to air pollutants and disease risk. Here, we investigate the mechanisms by which diesel exhaust, a major component of air pollution, induces neurotoxicity. Using a zebrafish model, we found that exposure to diesel exhaust particulate extract caused behavioral deficits and a significant decrease in neuron number. The neurotoxicity was due, at least in part, to reduced autophagic flux, which is a major pathway implicated in neurodegeneration. This neuron loss occurred alongside an increase in aggregation-prone neuronal protein. Additionally, the neurotoxicity induced by diesel exhaust particulate extract in zebrafish was mitigated by co-treatment with the autophagy-inducing drug nilotinib. This study links environmental exposure to altered proteostasis in an in vivo model system. These results shed light on why long-term exposure to traffic-related air pollution increases neurodegenerative disease risk and open up new avenues for exploring therapies to mitigate environmental exposures and promote neuroprotection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.