ArticleInvestigative ophthalmology & visual science2020
Features of the Choroidal Structures in Myopic Children Based on Image Binarization of Optical Coherence Tomography.
Article in Investigative ophthalmology & visual science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Potential Choroidal Mechanisms Underlying Atropine's Antimyopic and Rebound Effects: A Mediation Analysis in a Randomized Clinical Trial.Investigative ophthalmology & visual science · 2023Trial
- Effects of Atropine Treatment on Choroidal Thickness in Myopic Children.Investigative ophthalmology & visual science · 2020Trial
- Impact of Optical Coherence Tomography Scan Pattern and Chorio-Scleral Interface Delineation on Choroidal Vascularity Index Measurements.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Choroidal structural and perfusion characteristics across refractive groups in children.Frontiers in medicine · 2026Article
- Relationship between choroidal thickness changes and macrophage polarization in high myopia.Frontiers in medicine · 2026Review
- UWF-SS-OCTA evaluation of changes of choroidal microvasculature and microstructure in adult patients with high myopia and relationship with age and axial length.Frontiers in medicine · 2026Article
- Three-dimensional choroidal parameter differences in myopic anisometropia.BMC ophthalmology · 2025Article
- Age-Related Regional Changes in Choroidal Vascularity in Healthy Emmetropic Eyes.Translational vision science & technology · 2025Article
- Peripapillary choroidal vascularity of paediatric myopic eyes with peripapillary hyperreflective ovoid mass-like structures.Acta ophthalmologica · 2025Article
- Biometric parameters and choroidal microstructure in Chinese children with unilateral anisometropia.Frontiers in medicine · 2025Article
- The association between subfoveal choroidal thickness and refractive error in Taiwanese children: A cross-sectional study.PloS one · 2025Article
- Interocular differences in choroidal thickness and circulation in anisomyopic adults and their association with myopia severity.Frontiers in medicine · 2025Article
- Association of choroidal thickness and blood flow features with asymmetric axial lengths in children with unilateral myopic anisometropia.BMC ophthalmology · 2024Article
- Longitudinal Changes in Choroidal Vascularity in Myopic and Non-Myopic Children.Translational vision science & technology · 2024Article
- Choroidal vascularity features of fundus tessellation in adults with high myopia.BMC ophthalmology · 2024Article
- Establishment of an in vitro choroid complex system for vascular response screening.Scientific reports · 2024Article
- Quantitative Evaluation of the Topographical Maps of Three-Dimensional Choroidal Vascularity Index in Children With Different Degrees of Myopia.Investigative ophthalmology & visual science · 2024Article
- Choroidal Morphology and Photoreceptor Activity Are Related and Affected by Myopia Development.Investigative ophthalmology & visual science · 2024Article
- Choroidal vasculature act as predictive biomarkers of long-term ocular elongation in myopic children treated with orthokeratology: a prospective cohort study.Eye and vision (London, England) · 2023Article
- IMI-The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia.Investigative ophthalmology & visual science · 2023Review
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Authors and funding
6 authors.
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Abstract
Purpose: To evaluate the features of the choroidal structures in the eyes of myopic children obtained by enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: Ninety-six myopic children with low to moderate myopia (spherical equivalent refractive error [SER], -5.75 to -1.00 diopter) were included in this cross-sectional study. Ocular biometrics were measured using an optical low-coherence reflectometry device. Data of the choroidal structures extracted from a 7500-µm cross-sectional arc of the choroid extending from the temporal optic disc margin, including the total choroidal area, luminal area, stromal area, and choroidal vascularity index, were determined by image binarization of the EDI-OCT. Associations between demographic factors, ocular parameters, and choroidal structures were evaluated using univariate and multiple linear regression analyses. Results: The study participants (mean age, 11.02 ± 1.70 years) had a mean axial length (AL) of 24.94 ± 0.70 mm. The mean total choroidal area was 2.64 ± 0.49 mm2 (luminal area, 1.68 ± 0.32 mm2; stromal area, 0.95 ± 0.19 mm2), and the choroidal vascularity index was 0.64 ± 0.03. Multiple regression analysis showed that the luminal area was significantly associated with the AL (standard β = -0.24, P = 0.022) after adjusting for sex and corneal radius (CR), whereas the stromal area (standard β = -0.30, P = 0.003) and choroidal vascularity index (standard β = 0.36, P = 0.001) were significantly associated with age after adjusting for sex, CR, and lens thickness (LT). Sex, CR, LT, and SER showed no significant association with choroidal structures after adjusting for age and AL (all P > 0.05). Conclusions: The luminal area of the choroid tends to decrease with a longer AL, whereas the stromal area tends to decrease with increasing age in myopic children. These findings require further exploration in a longitudinal study.
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