Evidence map›Paper›PMID 32298211›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2020

Comprehensive stereological assessment of the human lung using multiresolution computed tomography.

Dragoş M Vasilescu, André B Phillion, Daisuke Kinose, Stijn E Verleden, Bart M Vanaudenaerde, Geert M Verleden, Dirk Van Raemdonck, Christopher S Stevenson, Cameron J Hague, MeiLan K Han and 3 more

Abstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Small Airway Disease in Pre-COPD and Early COPD: Insights Into the Pulmonary "Silent Zone".International journal of chronic obstructive pulmonary disease · 2026
    Review
  5. Article
  6. Article
  7. Flow mechanisms of the air-blood barrier.PLoS computational biology · 2025
    Article
  8. Integrins as Key Mediators of Metastasis.International journal of molecular sciences · 2025
    Review
  9. Article
  10. Microscopic Small Airway Abnormalities Identified in Early Idiopathic Pulmonary FibrosisAmerican journal of respiratory and critical care medicine · 2024
    Article
  11. Review
  12. Article
  13. Establishing a hemoglobin adjustment forMagnetic resonance in medicine · 2023
    Article
  14. Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dragoş M VasilescuCentre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0003-3936-4365
André B PhillionDepartment of Materials Science and Engineering, McMaster University, Hamilton, Ontario, Canada.
Daisuke KinoseCentre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.
Stijn E VerledenLeuven Lung Transplant Unit, Katholieke Universiteit Leuven and Universitair Ziekenhuis Leuven-Gasthuisberg, Leuven, Belgium.
Bart M VanaudenaerdeLeuven Lung Transplant Unit, Katholieke Universiteit Leuven and Universitair Ziekenhuis Leuven-Gasthuisberg, Leuven, Belgium.
Geert M VerledenLeuven Lung Transplant Unit, Katholieke Universiteit Leuven and Universitair Ziekenhuis Leuven-Gasthuisberg, Leuven, Belgium.
Dirk Van RaemdonckLeuven Lung Transplant Unit, Katholieke Universiteit Leuven and Universitair Ziekenhuis Leuven-Gasthuisberg, Leuven, Belgium.
Christopher S StevensonLung Cancer Initiative, Johnson and Johnson, Boston, Massachusetts.
Cameron J HagueDepartment of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.
MeiLan K HanDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan.
Joel D CooperDivision of Thoracic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.
Tillie-Louise HackettCentre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.
James C HoggCentre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.

Funding

Childhood Origins of CHD Disparities: Neural & Immune PathwaysR01HL122328 · NHLBI · NORTHWESTERN UNIVERSITY · PI MILLER, GREGORY EVAN · 2015 to 2018
$3.1M
Defining Pathways in COPD Patient Oriented ResearchK24HL138188 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MeiLan K Han · 2017 to 2026
$1.2M
CIHRNHLBI NIH HHS K24 HL138188NHLBI NIH HHS R01 HL122328
6 · The paper itself

Abstract

The application of stereology to lung casts and two-dimensional microscopy images is the gold standard for quantification of the human lung anatomy. However, these techniques are labor intensive, involving fixation, embedding, and histological sectioning of samples and thus have prevented comprehensive studies. Our objective was to demonstrate the application of stereology to volumetric multiresolution computed tomography (CT) to efficiently and extensively quantify the human lung anatomy. Nontransplantable donor lungs from individuals with no evidence of respiratory disease (

Indexed as

BronchiolesLungFemaleHumansLung Volume MeasurementsMalePulmonary AlveoliTomography, X-Ray Computedcomputed tomographyhumanlungmicro-CTstereology

Identifiers

PMID32298211
PMCPMC7311688

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.