ArticleJCO global oncology2020
Breast Cancer Survival in Sri Lanka.
Article in JCO global oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Pattern of Somatic Mutations in the PIK3CA Oncogene and Their Role as a Potential Prognostic Biomarker in Breast Cancer Patients in Sri Lanka: A Pilot Study.Asian Pacific journal of cancer prevention : APJCP · 2026Article
- Mechanistic study of antisense long non-coding RNAExploration of targeted anti-tumor therapy · 2026Article
- Identification of Genetic Variants Among Breast Cancer Patients and At-Risk Individuals: A Cohort Study in Sri Lanka.Breast cancer : basic and clinical research · 2026Article
- A Report from a Community-Centric Cancer Control Approach in the Post-Conflict Northern Province of Sri Lanka.International journal of environmental research and public health · 2025Article
- N7-methylguanosine (m7G) modification in breast cancer: clinical significances and molecular mechanisms.Cancer cell international · 2025Review
- Unveiling the prognostic significance of RNA editing-related genes in colon cancer: evidence from bioinformatics and experiment.European journal of medical research · 2025Article
- Wisely frugal: ensuring sustainable funding for novel cancer therapeutics through a budget impact analysis in resource-limited settings.Ecancermedicalscience · 2025Article
- Why do women with early breast cancer in Northern Sri Lanka undergo mastectomy? Decision-making and ways forward.BMC women's health · 2024Article
- Cost-utility and budget impact analysis of neoadjuvant dual HER2 targeted therapy for HER2-positive breast cancer in Sri Lanka.Scientific reports · 2024Article
- RETRACTED: The impact of breast-conserving surgery and modified radical mastectomy on postoperative wound complications in patients with early breast cancer.International wound journal · 2024Article
- Lung Cancer Survival in Sri Lanka.South Asian journal of cancer · 2023Article
- Patient Satisfaction With Breast Cancer Care Delivery at the National Cancer Institute of Sri Lanka: Does Language Play a Role?JCO global oncology · 2023Article
- Cervical Cancer in Sri Lanka.South Asian journal of cancer · 2023Article
- Relapse-free survival in Sudanese women with non-metastatic breast cancer.Global epidemiology · 2022Article
- Secondary and Quaternary Delays in the Diagnosis of Breast Cancer: Are the Physicians Responsible too?Indian journal of surgical oncology · 2022Article
- Mechanistic Insight into Apoptotic Induction in Human Rhabdomyosarcoma and Breast Adenocarcinoma Cells byPharmaceuticals (Basel, Switzerland) · 2021Article
- Demographic, tumour, and treatment characteristics of female patients with breast cancer in Sri Lanka; results from a hospital-based cancer registry.BMC cancer · 2021Article
- Docetaxel-induced interstitial lung disease among patients with breast cancer: a case series and review of literature.Respirology case reports · 2021Article
- Cancer services in Sri Lanka: current status and future directions.Journal of the Egyptian National Cancer Institute · 2021Review
- Ten-year survival outcome of breast cancer patients in India.Journal of carcinogenesis · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn this study, we report survival data of the largest cohort of patients with breast cancer in Sri Lanka. PATIENTS AND
methodsAll female patients with histologically confirmed breast cancer treated at a single unit at the National Cancer Institute of Sri Lanka between 1994 and 2006 were included in the study. Clinical records were reviewed and data obtained on the following clinical and pathologic factors: age, histology, stage at presentation, grade, and immunohistochemistry profile. Treatment details such as type of surgery and use of systemic chemotherapy, hormonal therapy, trastuzumab, and radiation therapy were also collected. In localized cancer, disease-free survival (DFS) was the primary end point, while in patients who presented with de novo metastases, progression-free survival (PFS) was the primary end point.
resultsA significant proportion of patients presented with de novo metastases (14%) and locally advanced disease (18%). While 57% of patients had hormone-sensitive tumors, human epidermal growth factor receptor 2 overexpression was seen in 14%, and 29% had triple-negative tumors. Only 3% of patients with localized disease were treated with breast-conserving surgery, with the rest undergoing modified radical mastectomy. The 5- year DFS rate was 71.6% (95% CI, 69.2 to 74.0) in patients with localized disease. The median PFS in patients with metastatic disease was 20 months (95% CI, 18 to 22 months), while the median overall survival was 30 months (95% CI, 32 to 35 months). On multivariable analysis, immunohistochemical group and stage were prognostic factors in localized disease, while in patients with metastases, immunohistochemical group and tumor grade were associated with PFS.
conclusionMore effective screening and early detection programs along with increasing breast-conserving surgery will improve breast cancer outcomes in Sri Lanka.
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