Evidence map›Paper›PMID 32298026›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2020

MHC class I and II peptide homology regulates the cellular immune response.

Matthew M Halpert, Vanaja Konduri, Dan Liang, Jonathan Vazquez-Perez, Colby J Hofferek, Scott A Weldon, Yunyu Baig, Indira Vedula, Jonathan M Levitt, William K Decker

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  11. CD8Frontiers in immunology · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Matthew M HalpertDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
Vanaja KonduriDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
Dan LiangDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
Jonathan Vazquez-PerezDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
Colby J HofferekDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
Scott A WeldonMichael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
Yunyu BaigDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
Indira VedulaDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
Jonathan M LevittDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
William K DeckerDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
Baylor College of Medicine · USChildren's Cancer Center · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BUTEL, JANET S · 1994 to 2015
$21.7M
Regulation of Innate Dendritic Cell CTLA-4R01AI127387 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI WILLIAM Karl DECKER · 2017 to 2026
$3.9M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574NIAID NIH HHS P30 AI036211NIAID NIH HHS R01 AI127387
6 · The paper itself

Abstract

Mammalian immune responses are initiated by "danger" signals--immutable molecular structures known as PAMPs. When detected by fixed, germline encoded receptors, pathogen-associated molecular pattern (PAMPs) subsequently inform the polarization of downstream adaptive responses depending upon identity and localization of the PAMP. Here, we report the existence of a completely novel "PAMP" that is not a molecular structure but an antigenic pattern. This pattern--the incidence of peptide epitopes with stretches of 100% sequence identity bound to both dendritic cell (DC) major histocompatibility (MHC) class I and MHC class II--strongly induces T

Indexed as

Amino Acid SequenceAmino Acyl-tRNA SynthetasesAnimalsDendritic CellsHistocompatibility Antigens Class IHistocompatibility Antigens Class IIImmunity, CellularMiceMice, Inbred BALB CMice, Inbred C57BLPeptidesTh1 CellsAmino Acyl-tRNA SynthetasesHistocompatibility Antigens Class IHistocompatibility Antigens Class IIPeptidesAIMp1CTLA-4dendritic cellPAMPPRRTH1 polarization

Identifiers

PMID32298026
PMCPMC7493300
OpenAlexW3016889218

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.