Evidence map›Paper›PMID 32297936›Full record

ArticleNucleic acids research2020

ProteinsPlus: interactive analysis of protein-ligand binding interfaces.

Katrin Schöning-Stierand, Konrad Diedrich, Rainer Fährrolfes, Florian Flachsenberg, Agnes Meyder, Eva Nittinger, Ruben Steinegger, Matthias Rarey

Abstract read
In one paragraph

Article in Nucleic acids research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed.

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  10. Inhibitory Effect ofTheScientificWorldJournal · 2026
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52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katrin Schöning-StierandUniversität Hamburg, ZBH - Center for Bioinformatics (ZBH), 20146 Hamburg, Germany.
Konrad DiedrichUniversität Hamburg, ZBH - Center for Bioinformatics (ZBH), 20146 Hamburg, Germany.
Rainer FährrolfesUniversität Hamburg, ZBH - Center for Bioinformatics (ZBH), 20146 Hamburg, Germany.
Florian FlachsenbergUniversität Hamburg, ZBH - Center for Bioinformatics (ZBH), 20146 Hamburg, Germany.
Agnes MeyderUniversität Hamburg, ZBH - Center for Bioinformatics (ZBH), 20146 Hamburg, Germany.
Eva NittingerUniversität Hamburg, ZBH - Center for Bioinformatics (ZBH), 20146 Hamburg, Germany.
Ruben SteineggerUniversität Hamburg, ZBH - Center for Bioinformatics (ZBH), 20146 Hamburg, Germany.
Matthias RareyUniversität Hamburg, ZBH - Center for Bioinformatics (ZBH), 20146 Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to the increasing amount of publicly available protein structures searching, enriching and investigating these data still poses a challenging task. The ProteinsPlus web service (https://proteins.plus) offers a broad range of tools addressing these challenges. The web interface to the tool collection focusing on protein-ligand interactions has been geared towards easy and intuitive access to a large variety of functionality for life scientists. Since our last publication, the ProteinsPlus web service has been extended by additional services as well as it has undergone substantial infrastructural improvements. A keyword search functionality was added on the start page of ProteinsPlus enabling users to work on structures without knowing their PDB code. The tool collection has been augmented by three tools: StructureProfiler validates ligands and active sites using selection criteria of well-established protein-ligand benchmark data sets, WarPP places water molecules in the ligand binding sites of a protein, and METALizer calculates, predicts and scores coordination geometries of metal ions based on surrounding complex atoms. Additionally, all tools provided by ProteinsPlus are available through a REST service enabling the automated integration in structure processing and modeling pipelines.

Indexed as

SoftwareBinding SitesLigandsMetalsModels, MolecularProteinsWaterLigandsMetalsProteinsWater

Identifiers

PMID32297936
PMCPMC7319454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.