ArticleExperimental and clinical psychopharmacology2021
Conditioned enhancement of the nicotine reinforcer.
Article in Experimental and clinical psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- An examination of the interaction between the interoceptive and reinforcing properties of morphine: a self-administration study in male and female rats.Psychopharmacology · 2026Article
- The inside story: Interoceptive Pavlovian conditioning with the nicotine stimulus.Journal of experimental psychology. Animal learning and cognition · 2025Review
- Adapting a Functional Assessment of Cigarette Smoking for People with Intellectual and Developmental Disabilities.Behavior analysis in practice · 2025Article
- Pavlovian conditioning with the internal stimulus effects of intravenous nicotine heightens later nicotine taking with variation by dose and sex.Scientific reports · 2025Article
- Acute nicotine administration reduces the efficacy of punishment in curbing remifentanil consumption in a seeking-taking chain schedule of reinforcement.Psychopharmacology · 2024Article
- Assessment of ethanol and nicotine interactions using a reinforcer demand modeling with grouped and individual levels of analyses in a long-access self-administration model using male rats.Frontiers in behavioral neuroscience · 2023Article
- Acute nicotine treatment enhances compulsive-like remifentanil self-administration that persists despite contextual punishment.Addiction biology · 2022Article
- Appetitive Pavlovian conditioning of the stimulus effects of nicotine enhances later nicotine self-administration.Journal of the experimental analysis of behavior · 2022Article
- Stimulus functions of nicotine.Advances in pharmacology (San Diego, Calif.) · 2022Article
- Investigating sex differences and the effect of drug exposure order in the sensory reward-enhancing effects of nicotine and d-amphetamine alone and in combination.Neuropharmacology · 2022Article
- Inactivation of posterior but not anterior dorsomedial caudate-putamen impedes learning with self-administered nicotine stimulus in male rats.Behavioural brain research · 2021Article
- Reward-enhancing effects of d-amphetamine and its interactions with nicotine were greater in female rats and persisted across schedules of reinforcement.Behavioural pharmacology · 2021Article
- Varenicline rescues nicotine-induced decrease in motivation for sucrose reinforcement.Behavioural brain research · 2021Article
- High-dose adolescent nicotine exposure permits spontaneous nicotine self-administration in adult male rats.Drug and alcohol dependence · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
This study was designed to assess whether nicotine can acquire additional reinforcing properties through associations with other rewards. To this end, rats self-administered nicotine-alone (0.01 mg/kg) or nicotine paired with access to sucrose during the conditioning phase. In the subsequent challenge phase, we tested the effect of nicotine-sucrose pairings on the reinforcing effects of nicotine using a progressive ratio schedule of reinforcement. Using this approach, we show that (a) rats in both paired and nicotine-alone conditions self-administered similar amounts of nicotine in the initial conditioning phase of the study when intake was limited to 10 infusions per session, (b) nicotine rapidly acquired control over goal-tracking behavior in the paired condition, (c) rats that had a history of nicotine and sucrose pairings worked harder and took more nicotine as measured on a progressive ratio using a distinct response form, and (d) conditioned goal-tracking evoked by nicotine did not show extinction when sucrose was no longer paired with nicotine over the 11 days of nicotine self-administration on a progressive ratio schedule of reinforcement. Overall, our results demonstrate that in addition to the multifaceted nature of nicotine stimulus that includes primary reinforcing effects, conditioned reinforcing effects, and reward enhancing effects, nicotine can also acquire additional reinforcing properties through associations with other rewards. This ability to acquire additional reinforcing properties through associative learning may contribute to the development and perpetuation of tobacco use disorder. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
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